Mechanism of Selective VEGF-A Binding by Neuropilin-1 Reveals a Basis for Specific Ligand Inhibition

Matthew W. Parker; Ping Xu; Hou-Fu Guo; Craig W. Vander Kooi

doi:10.1371/journal.pone.0049177

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Open Access

Peer-reviewed

Research Article

Mechanism of Selective VEGF-A Binding by Neuropilin-1 Reveals a Basis for Specific Ligand Inhibition

Matthew W. Parker,

Affiliation Department of Molecular and Cellular Biochemistry and Center for Structural Biology, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Ping Xu,

Affiliation Department of Molecular and Cellular Biochemistry and Center for Structural Biology, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Hou-Fu Guo,

Affiliation Department of Molecular and Cellular Biochemistry and Center for Structural Biology, University of Kentucky, Lexington, Kentucky, United States of America
⨯
Craig W. Vander Kooi

* E-mail: craig.vanderkooi@uky.edu

Affiliation Department of Molecular and Cellular Biochemistry and Center for Structural Biology, University of Kentucky, Lexington, Kentucky, United States of America
⨯

Mechanism of Selective VEGF-A Binding by Neuropilin-1 Reveals a Basis for Specific Ligand Inhibition

Matthew W. Parker,
Ping Xu,
Hou-Fu Guo,
Craig W. Vander Kooi

Published: November 8, 2012
https://doi.org/10.1371/journal.pone.0049177

About the Authors

Matthew W. Parker

Affiliation Department of Molecular and Cellular Biochemistry and Center for Structural Biology, University of Kentucky, Lexington, Kentucky, United States of America

Ping Xu

Affiliation Department of Molecular and Cellular Biochemistry and Center for Structural Biology, University of Kentucky, Lexington, Kentucky, United States of America

Hou-Fu Guo

Affiliation Department of Molecular and Cellular Biochemistry and Center for Structural Biology, University of Kentucky, Lexington, Kentucky, United States of America

Craig W. Vander Kooi

* E-mail: craig.vanderkooi@uky.edu

Affiliation Department of Molecular and Cellular Biochemistry and Center for Structural Biology, University of Kentucky, Lexington, Kentucky, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MWP PX H-FG CWVK. Performed the experiments: MWP PX H-FG. Analyzed the data: MWP CWVK. Wrote the paper: MWP CWVK.

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Arginine
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Coagulation factors
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Signal processing
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VEGF signaling
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Protein domains
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Axon guidance receptors
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Regeneration
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Spinal cord injury
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