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Research Article

Inconsistent Definitions for Intention-To-Treat in Relation to Missing Outcome Data: Systematic Review of the Methods Literature

  • Mohamad Alshurafa equal contributor,

    equal contributor Contributed equally to this work with: Mohamad Alshurafa, Matthias Briel

    Affiliation: Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada

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  • Matthias Briel equal contributor mail,

    equal contributor Contributed equally to this work with: Mohamad Alshurafa, Matthias Briel

    brielm@uhbs.ch

    Affiliations: Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada, Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland

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  • Elie A. Akl,

    Affiliations: Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada, Departments of Medicine and Family Medicine, State University of New York at Buffalo, Buffalo, United States of America

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  • Ted Haines,

    Affiliation: Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada

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  • Paul Moayyedi,

    Affiliations: Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada, Department of Medicine, McMaster University, Hamilton, Canada

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  • Stephen J. Gentles,

    Affiliation: Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada

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  • Lorena Rios,

    Affiliation: Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada

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  • Chau Tran,

    Affiliation: Chau Tran Consulting, Toronto, Canada

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  • Neera Bhatnagar,

    Affiliation: Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada

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  • Francois Lamontagne,

    Affiliation: Centre de Recherche Clinique Étienne-Le Bel, Université de Sherbrooke, Sherbrooke, Canada

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  • Stephen D. Walter,

    Affiliation: Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada

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  • Gordon H. Guyatt

    Affiliations: Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada, Department of Medicine, McMaster University, Hamilton, Canada

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  • Published: November 15, 2012
  • DOI: 10.1371/journal.pone.0049163
  • Featured in PLOS Collections

About the Authors

Mohamad Alshurafa, Matthias Briel, Elie A. Akl, Ted Haines, Paul Moayyedi, Stephen J. Gentles, Lorena Rios, Neera Bhatnagar, Stephen D. Walter, Gordon H. Guyatt
Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, Canada
Matthias Briel
Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland
Elie A. Akl
Departments of Medicine and Family Medicine, State University of New York at Buffalo, Buffalo, United States of America
Paul Moayyedi, Gordon H. Guyatt
Department of Medicine, McMaster University, Hamilton, Canada
Chau Tran
Chau Tran Consulting, Toronto, Canada
Francois Lamontagne
Centre de Recherche Clinique Étienne-Le Bel, Université de Sherbrooke, Sherbrooke, Canada

Corresponding Author

Email: brielm@uhbs.ch

Competing Interests

All authors declare that they received no support from any organisation for the submitted work; that they have no financial relationships with any organisations that might have an interest in the submitted work in the previous three years; that they have no other relationships or activities that could appear to have influenced the submitted work.

Author Contributions

Conceived and designed the experiments: MA MB EAA SDW TH FL GHG. Analyzed the data: MA MB. Contributed reagents/materials/analysis tools: SDW PM GHG. Wrote the paper: MA MB GHG. Conducted the study: MA MB EAA TH NB SJG LR FL CT TH SDW GHG. Reviewed the manuscript for important intellectual content: EAA TH NB SJG LR FL CT TH SDW PM.