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Research Article

Longitudinal Study of Mammary Epithelial and Fibroblast Co-Cultures Using Optical Coherence Tomography Reveals Morphological Hallmarks of Pre-Malignancy

  • Raghav K. Chhetri,

    Affiliation: Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Zachary F. Phillips,

    Affiliation: Curriculum in Applied Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Melissa A. Troester,

    Affiliation: Lineberger Comprehensive Cancer Center/Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Amy L. Oldenburg mail

    aold@physics.unc.edu

    Affiliations: Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America, Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

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  • Published: November 12, 2012
  • DOI: 10.1371/journal.pone.0049148

About the Authors

Raghav K. Chhetri, Amy L. Oldenburg
Department of Physics and Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Zachary F. Phillips
Curriculum in Applied Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Melissa A. Troester
Lineberger Comprehensive Cancer Center/Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
Amy L. Oldenburg
Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America

Corresponding Author

Email: aold@physics.unc.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RKC ZFP MAT ALO. Performed the experiments: RKC ZFP MAT ALO. Analyzed the data: RKC ZFP MAT ALO. Contributed reagents/materials/analysis tools: RKC ZFP MAT ALO. Wrote the paper: RKC ZFP MAT ALO.