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Research Article

High-Throughput MicroRNA (miRNAs) Arrays Unravel the Prognostic Role of MiR-211 in Pancreatic Cancer

  • Elisa Giovannetti mail,

    elisa.giovannetti@gmail.com

    Affiliation: Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands

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  • Arjan van der Velde,

    Affiliation: Centre Integrative Bioinformatics, VU University, Amsterdam, The Netherlands

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  • Niccola Funel,

    Affiliation: Department of Surgical Pathology, University of Pisa, Pisa, Italy

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  • Enrico Vasile,

    Affiliation: Azienda Ospedaliera Universitaria Pisana, Istituto Tumori Toscano, Pisa, Italy

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  • Vittorio Perrone,

    Affiliation: Department of General Surgery and Transplants, University of Pisa, Pisa, Italy

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  • Leticia G. Leon,

    Affiliation: Centre Integrative Bioinformatics, VU University, Amsterdam, The Netherlands

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  • Nelide De Lio,

    Affiliation: Department of General Surgery and Transplants, University of Pisa, Pisa, Italy

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  • Amir Avan,

    Affiliation: Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands

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  • Sara Caponi,

    Affiliation: Azienda Ospedaliera Universitaria Pisana, Istituto Tumori Toscano, Pisa, Italy

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  • Luca E. Pollina,

    Affiliation: Department of Surgical Pathology, University of Pisa, Pisa, Italy

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  • Valentina Gallá,

    Affiliation: Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands

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  • Hiroko Sudo,

    Affiliation: New Frontiers Research Laboratories, Toray Industries Inc., Kanagawa, Japan

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  • Alfredo Falcone,

    Affiliation: Azienda Ospedaliera Universitaria Pisana, Istituto Tumori Toscano, Pisa, Italy

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  • Daniela Campani,

    Affiliation: Department of Surgical Pathology, University of Pisa, Pisa, Italy

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  • Ugo Boggi equal contributor,

    equal contributor Contributed equally to this work with: Ugo Boggi, Godefridus J. Peters

    Affiliation: Department of General Surgery and Transplants, University of Pisa, Pisa, Italy

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  • Godefridus J. Peters equal contributor

    equal contributor Contributed equally to this work with: Ugo Boggi, Godefridus J. Peters

    Affiliation: Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands

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  • Published: November 14, 2012
  • DOI: 10.1371/journal.pone.0049145

About the Authors

Elisa Giovannetti, Amir Avan, Valentina Gallá, Godefridus J. Peters
Department of Medical Oncology, VU University Medical Center, Amsterdam, The Netherlands
Arjan van der Velde, Leticia G. Leon
Centre Integrative Bioinformatics, VU University, Amsterdam, The Netherlands
Niccola Funel, Luca E. Pollina, Daniela Campani
Department of Surgical Pathology, University of Pisa, Pisa, Italy
Enrico Vasile, Sara Caponi, Alfredo Falcone
Azienda Ospedaliera Universitaria Pisana, Istituto Tumori Toscano, Pisa, Italy
Vittorio Perrone, Nelide De Lio, Ugo Boggi
Department of General Surgery and Transplants, University of Pisa, Pisa, Italy
Hiroko Sudo
New Frontiers Research Laboratories, Toray Industries Inc., Kanagawa, Japan

Corresponding Author

Email: elisa.giovannetti@gmail.com

Competing Interests

The authors have declared that no competing interests exist. In this study, the authors use products of Toray Industries, Inc., 3D-GeneTM”for the miRNA microarray, but this does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: EG AV LGL NF EV. Performed the experiments: EG AA HS VG. Analyzed the data: EG AV LGL. Contributed reagents/materials/analysis tools: GJP HS UB EG AF. Wrote the paper: EG AV GJP. Obtained and analyzed tissue samples: DC LEP VP ND. Contributed to the analysis of clinical database: SC.