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Research Article

Effects of PPARγ and RBP4 Gene Variants on Metabolic Syndrome in HIV-Infected Patients with Anti-Retroviral Therapy

  • Yuan-Pin Hung,

    Affiliations: Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan, Department of Internal Medicine, Tainan Hospital, Department of Health, Executive Yuan, Tainan, Taiwan

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  • Nan-Yao Lee,

    Affiliations: Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, Center for Infection Control, National Cheng Kung University Hospital, Tainan, Taiwan

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  • Sheng-Hsiang Lin,

    Affiliation: Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan

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  • Ho-Ching Chang,

    Affiliation: Department of Nutrition, Chi-Mei Hospital, Tainan, Taiwan

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  • Chi-Jung Wu,

    Affiliations: Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan, Division of Clinical Research, National Health Research Institutes, Tainan, Taiwan

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  • Chia-Ming Chang,

    Affiliations: Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, Center for Infection Control, National Cheng Kung University Hospital, Tainan, Taiwan

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  • Po-Lin Chen,

    Affiliations: Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan

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  • Hsiao-Ju Lin,

    Affiliations: Department of Internal Medicine, Tainan Hospital, Department of Health, Executive Yuan, Tainan, Taiwan, Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan

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  • Yi-Hui Wu,

    Affiliations: Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, Department of Internal Medicine, Pingtung Christian Hospital, Pingtung, Taiwan

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  • Pei-Jane Tsai,

    Affiliations: Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, Tainan, Taiwan, Research Center of Infectious Disease and Signaling, National Cheng Kung University, Tainan, Taiwan

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  • Yau-Sheng Tsai equal contributor mail,

    equal contributor Contributed equally to this work with: Yau-Sheng Tsai, Wen-Chien Ko

    winston@mail.ncku.edu.tw (WCK); yaustsai@mail.ncku.edu.tw (YST)

    Affiliations: Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan, Research Center of Infectious Disease and Signaling, National Cheng Kung University, Tainan, Taiwan

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  • Wen-Chien Ko equal contributor mail

    equal contributor Contributed equally to this work with: Yau-Sheng Tsai, Wen-Chien Ko

    winston@mail.ncku.edu.tw (WCK); yaustsai@mail.ncku.edu.tw (YST)

    Affiliations: Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan, Center for Infection Control, National Cheng Kung University Hospital, Tainan, Taiwan, Research Center of Infectious Disease and Signaling, National Cheng Kung University, Tainan, Taiwan, Department of Medicine, National Cheng Kung University, Tainan, Taiwan

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  • Published: November 07, 2012
  • DOI: 10.1371/journal.pone.0049102

About the Authors

Yuan-Pin Hung, Sheng-Hsiang Lin, Chi-Jung Wu, Po-Lin Chen, Yau-Sheng Tsai
Institute of Clinical Medicine, National Cheng Kung University, Tainan, Taiwan
Yuan-Pin Hung, Hsiao-Ju Lin
Department of Internal Medicine, Tainan Hospital, Department of Health, Executive Yuan, Tainan, Taiwan
Nan-Yao Lee, Chia-Ming Chang, Po-Lin Chen, Hsiao-Ju Lin, Yi-Hui Wu, Wen-Chien Ko
Department of Internal Medicine, National Cheng Kung University Hospital, Tainan, Taiwan
Nan-Yao Lee, Chia-Ming Chang, Wen-Chien Ko
Center for Infection Control, National Cheng Kung University Hospital, Tainan, Taiwan
Ho-Ching Chang
Department of Nutrition, Chi-Mei Hospital, Tainan, Taiwan
Chi-Jung Wu
Division of Clinical Research, National Health Research Institutes, Tainan, Taiwan
Yi-Hui Wu
Department of Internal Medicine, Pingtung Christian Hospital, Pingtung, Taiwan
Pei-Jane Tsai
Department of Medical Laboratory Science and Biotechnology, National Cheng Kung University, Tainan, Taiwan
Pei-Jane Tsai, Yau-Sheng Tsai, Wen-Chien Ko
Research Center of Infectious Disease and Signaling, National Cheng Kung University, Tainan, Taiwan
Wen-Chien Ko
Department of Medicine, National Cheng Kung University, Tainan, Taiwan

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YPH YST WCK. Performed the experiments: YPH NYL HCC CJW CMC PLC. Analyzed the data: HJL YHW PJT SHL. Contributed reagents/materials/analysis tools: HJL YHW PJT. Wrote the paper: YPH YST WCK.