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Research Article

A Common Trinucleotide Repeat Expansion within the Transcription Factor 4 (TCF4, E2-2) Gene Predicts Fuchs Corneal Dystrophy

  • Eric D. Wieben,

    Affiliation: Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Ross A. Aleff,

    Affiliation: Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Nirubol Tosakulwong,

    Affiliation: Department of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Malinda L. Butz,

    Affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America

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  • W. Edward Highsmith,

    Affiliation: Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Albert O. Edwards,

    Affiliation: Institute for Molecular Biology, University of Oregon and Oregon Retina, Eugene, Oregon, United States of America

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  • Keith H. Baratz mail

    baratz.keith@mayo.edu

    Affiliation: Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, United States of America

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  • Published: November 21, 2012
  • DOI: 10.1371/journal.pone.0049083

About the Authors

Eric D. Wieben, Ross A. Aleff
Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, United States of America
Nirubol Tosakulwong
Department of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota, United States of America
Malinda L. Butz, W. Edward Highsmith
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, United States of America
Albert O. Edwards
Institute for Molecular Biology, University of Oregon and Oregon Retina, Eugene, Oregon, United States of America
Keith H. Baratz
Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, United States of America

Corresponding Author

Email: baratz.keith@mayo.edu

Competing Interests

EDW, RAA, AOE and KHB have filed a patent application, assessing the likelihood of developing Fuchs corneal dystrophy. The patent has not been approved yet and no money has been gained. Patent application number: 61581889. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: EDW RAA NT MLB WEH AOE KHB. Performed the experiments: RAA NT MLB WEH AOE KHB. Analyzed the data: EDW NT KHB. Contributed reagents/materials/analysis tools: RAA NT MLB WEH. Wrote the paper: EDW RAA NT MLB WEH AOE KHB.