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Research Article

IgG Responses to Pneumococcal and Haemophilus Influenzae Protein Antigens Are Not Impaired in Children with a History of Recurrent Acute Otitis Media

  • Selma P. Wiertsema mail,

    swiertsema@meddent.uwa.edu.au (SPW); lkirkham@meddent.uwa.edu.au (LSK)

    Affiliations: School of Paediatrics and Child Health, University of Western Australia, Perth, Australia, Centre for Child Health Research, Telethon Institute for Child Health Research, Perth, Australia

    Current address: Crucell, Leiden, The Netherlands

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  • Karli J. Corscadden,

    Affiliation: Centre for Child Health Research, Telethon Institute for Child Health Research, Perth, Australia

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  • Eva N. Mowe,

    Affiliation: Centre for Child Health Research, Telethon Institute for Child Health Research, Perth, Australia

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  • Guicheng Zhang,

    Affiliation: School of Paediatrics and Child Health, University of Western Australia, Perth, Australia

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  • Shyan Vijayasekaran,

    Affiliation: Department of Otolaryngology, Head and Neck Surgery, University of Western Australia, Perth, Australia

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  • Harvey L. Coates,

    Affiliation: Department of Otolaryngology, Head and Neck Surgery, University of Western Australia, Perth, Australia

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  • Timothy J. Mitchell,

    Affiliation: Division of Infection and Immunity, University of Glasgow, Glasgow, United Kingdom

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  • Wayne R. Thomas,

    Affiliation: Centre for Child Health Research, Telethon Institute for Child Health Research, Perth, Australia

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  • Peter C. Richmond,

    Affiliations: School of Paediatrics and Child Health, University of Western Australia, Perth, Australia, Centre for Child Health Research, Telethon Institute for Child Health Research, Perth, Australia

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  • Lea-Ann S. Kirkham mail

    swiertsema@meddent.uwa.edu.au (SPW); lkirkham@meddent.uwa.edu.au (LSK)

    Affiliations: School of Paediatrics and Child Health, University of Western Australia, Perth, Australia, Centre for Child Health Research, Telethon Institute for Child Health Research, Perth, Australia

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  • Published: November 12, 2012
  • DOI: 10.1371/journal.pone.0049061

About the Authors

Selma P. Wiertsema, Guicheng Zhang, Peter C. Richmond, Lea-Ann S. Kirkham
School of Paediatrics and Child Health, University of Western Australia, Perth, Australia
Selma P. Wiertsema, Karli J. Corscadden, Eva N. Mowe, Wayne R. Thomas, Peter C. Richmond, Lea-Ann S. Kirkham
Centre for Child Health Research, Telethon Institute for Child Health Research, Perth, Australia
Shyan Vijayasekaran, Harvey L. Coates
Department of Otolaryngology, Head and Neck Surgery, University of Western Australia, Perth, Australia
Timothy J. Mitchell
Division of Infection and Immunity, University of Glasgow, Glasgow, United Kingdom

Corresponding Authors

Competing Interests

SW and LK have received institutional funding for studies investigating bacterial pathogens in children with rAOM and travel funding from GlaxoSmithKline. TM has received institutional funding from Wyeth Vaccines and GlaxoSmithKline. LK and TM are co-inventors on patents PCT/GB2007/002242, PCT/GB2005/001792 and PCT/GB2005/001774. HC and SV have served as consultants and have received travel funding from GlaxoSmithKline Biologicals. PR has received institutional funding for epidemiological research from GlaxoSmithKline and CSL and served on advisory boards for CSL and Wyeth Vaccines. All other authors have indicated they have no conflicts of interest.

Author Contributions

Conceived and designed the experiments: SW KC PR WT TM SV HC LK. Performed the experiments: SW KC LK EM. Analyzed the data: SW GZ KC LK PR. Contributed reagents/materials/analysis tools: SV HC WT TM. Wrote the paper: SW GZ KC LK WT PR.