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Research Article

Deletion of CDKAL1 Affects High-Fat Diet–Induced Fat Accumulation and Glucose-Stimulated Insulin Secretion in Mice, Indicating Relevance to Diabetes

  • Tadashi Okamura equal contributor,

    equal contributor Contributed equally to this work with: Tadashi Okamura, Rieko Yanobu-Takanashi

    Affiliation: Division of Animal Model, Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

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  • Rieko Yanobu-Takanashi equal contributor,

    equal contributor Contributed equally to this work with: Tadashi Okamura, Rieko Yanobu-Takanashi

    Affiliation: Division of Animal Model, Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

    X
  • Fumihiko Takeuchi,

    Affiliation: Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

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  • Masato Isono,

    Affiliation: Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

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  • Koichi Akiyama,

    Affiliation: Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

    X
  • Yukiko Shimizu,

    Affiliation: Division of Animal Model, Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

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  • Motohito Goto,

    Affiliation: Division of Animal Model, Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

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  • Yi-Qiang Liang,

    Affiliation: Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

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  • Ken Yamamoto,

    Affiliation: Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan

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  • Tomohiro Katsuya,

    Affiliations: Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan, Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Japan

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  • Akihiro Fujioka,

    Affiliation: Amagasaki Health Medical Foundation, Amagasaki Japan

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  • Keizo Ohnaka,

    Affiliation: Department of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

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  • Ryoichi Takayanagi,

    Affiliation: Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

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  • Toshio Ogihara,

    Affiliations: Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Japan, Morinomiya University of Medical Sciences, Osaka, Japan

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  • Yukio Yamori,

    Affiliation: Mukogawa Women’s University Institute for World Health Development, Mukogawa, Japan

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  • Norihiro Kato mail

    nokato@ri.ncgm.go.jp

    Affiliation: Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

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  • Published: November 16, 2012
  • DOI: 10.1371/journal.pone.0049055

About the Authors

Tadashi Okamura, Rieko Yanobu-Takanashi, Yukiko Shimizu, Motohito Goto
Division of Animal Model, Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
Fumihiko Takeuchi, Masato Isono, Koichi Akiyama, Yi-Qiang Liang, Norihiro Kato
Department of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan
Ken Yamamoto
Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
Tomohiro Katsuya
Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan
Tomohiro Katsuya, Toshio Ogihara
Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Japan
Akihiro Fujioka
Amagasaki Health Medical Foundation, Amagasaki Japan
Keizo Ohnaka
Department of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Ryoichi Takayanagi
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Toshio Ogihara
Morinomiya University of Medical Sciences, Osaka, Japan
Yukio Yamori
Mukogawa Women’s University Institute for World Health Development, Mukogawa, Japan

Corresponding Author

Email: nokato@ri.ncgm.go.jp

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: NK T. Okamura. Performed the experiments: RYT MI KA YS MG YQL. Analyzed the data: T. Okamura FT KY. Contributed reagents/materials/analysis tools: TK AF KO RT T. Ogihara YY. Wrote the paper: NK.