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Research Article

Oncogenic Kit Triggers Shp2/Erk1/2 Pathway to Down-Regulate the Pro-Apoptotic Protein Bim and to Promote Apoptosis Resistance in Leukemic Cells

  • Dorothée Selimoglu-Buet,

    Affiliation: Institut Curie, Inserm-U830, Paris, France

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  • Isabelle Gallais,

    Affiliation: Institut Curie, Inserm-U830, Paris, France

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  • Nicole Denis,

    Affiliation: Institut Curie, Inserm-U830, Paris, France

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  • Christel Guillouf,

    Affiliation: Institut Curie, Inserm-U830, Paris, France

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  • Françoise Moreau-Gachelin mail

    framoreau@curie.fr

    Affiliation: Institut Curie, Inserm-U830, Paris, France

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  • Published: November 07, 2012
  • DOI: 10.1371/journal.pone.0049052

About the Authors

Dorothée Selimoglu-Buet, Isabelle Gallais, Nicole Denis, Christel Guillouf, Françoise Moreau-Gachelin
Institut Curie, Inserm-U830, Paris, France

Corresponding Author

Email: framoreau@curie.fr

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DSB FMG. Performed the experiments: DSB IG ND. Analyzed the data: DSB CG FMG. Contributed reagents/materials/analysis tools: DSB IG ND. Wrote the paper: DSB FMG.