# wombat urls ß PLOS ONE: Gene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans
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Research Article

Gene Expression-Based Classifiers Identify Staphylococcus aureus Infection in Mice and Humans

  • Sun Hee Ahn equal contributor,

    equal contributor Contributed equally to this work with: Sun Hee Ahn, Ephraim L. Tsalik

    Affiliation: Division of Infectious Diseases and International Health, Department of Medicine, Duke University, Durham, North Carolina, United States of America

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  • Ephraim L. Tsalik equal contributor,

    equal contributor Contributed equally to this work with: Sun Hee Ahn, Ephraim L. Tsalik

    Affiliations: Division of Infectious Diseases and International Health, Department of Medicine, Duke University, Durham, North Carolina, United States of America, Section on Infectious Diseases, Durham Veteran’s Affairs Medical Center, Durham, North Carolina, United States of America

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  • Derek D. Cyr,

    Affiliation: Duke Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America

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  • Yurong Zhang,

    Affiliation: Division of Infectious Diseases and International Health, Department of Medicine, Duke University, Durham, North Carolina, United States of America

    X
  • Jennifer C. van Velkinburgh,

    Affiliation: van Velkinburgh Initiative for Collaborative BioMedical Research, Santa Fe, New Mexico, United States of America

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  • Raymond J. Langley,

    Affiliation: Immunology Division, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, United States of America

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  • Seth W. Glickman,

    Affiliation: Department of Emergency Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

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  • Charles B. Cairns,

    Affiliation: Department of Emergency Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

    X
  • Aimee K. Zaas,

    Affiliations: Division of Infectious Diseases and International Health, Department of Medicine, Duke University, Durham, North Carolina, United States of America, Duke Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America

    X
  • Emanuel P. Rivers,

    Affiliation: Department of Emergency Medicine, Henry Ford Hospital, Wayne State University, Detroit, Michigan, United States of America

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  • Ronny M. Otero,

    Affiliation: Department of Emergency Medicine, Henry Ford Hospital, Wayne State University, Detroit, Michigan, United States of America

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  • Tim Veldman,

    Affiliation: Duke Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America

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  • Stephen F. Kingsmore,

    Affiliation: Center for Pediatric Genomic Medicine, Children’s Mercy Hospitals and Clinics, Kansas City, Missouri, United States of America

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  • Joseph Lucas,

    Affiliation: Duke Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America

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  • Christopher W. Woods,

    Affiliations: Division of Infectious Diseases and International Health, Department of Medicine, Duke University, Durham, North Carolina, United States of America, Section on Infectious Diseases, Durham Veteran’s Affairs Medical Center, Durham, North Carolina, United States of America, Duke Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America

    X
  • Geoffrey S. Ginsburg mail,

    Geoffrey.ginsburg@duke.edu (GSG); vance.fowler@duke.edu (VGF)

    Affiliation: Duke Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America

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  • Vance G. Fowler Jr mail

    Geoffrey.ginsburg@duke.edu (GSG); vance.fowler@duke.edu (VGF)

    Affiliations: Division of Infectious Diseases and International Health, Department of Medicine, Duke University, Durham, North Carolina, United States of America, Duke Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America, Duke Clinical Research Institute, Durham, North Carolina, United States of America

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  • Published: January 09, 2013
  • DOI: 10.1371/journal.pone.0048979

About the Authors

Sun Hee Ahn, Ephraim L. Tsalik, Yurong Zhang, Aimee K. Zaas, Christopher W. Woods, Vance G. Fowler Jr
Division of Infectious Diseases and International Health, Department of Medicine, Duke University, Durham, North Carolina, United States of America
Ephraim L. Tsalik, Christopher W. Woods
Section on Infectious Diseases, Durham Veteran’s Affairs Medical Center, Durham, North Carolina, United States of America
Derek D. Cyr, Aimee K. Zaas, Tim Veldman, Joseph Lucas, Christopher W. Woods, Geoffrey S. Ginsburg, Vance G. Fowler Jr
Duke Institute for Genome Sciences and Policy, Duke University, Durham, North Carolina, United States of America
Jennifer C. van Velkinburgh
van Velkinburgh Initiative for Collaborative BioMedical Research, Santa Fe, New Mexico, United States of America
Raymond J. Langley
Immunology Division, Lovelace Respiratory Research Institute, Albuquerque, New Mexico, United States of America
Seth W. Glickman, Charles B. Cairns
Department of Emergency Medicine, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America
Emanuel P. Rivers, Ronny M. Otero
Department of Emergency Medicine, Henry Ford Hospital, Wayne State University, Detroit, Michigan, United States of America
Stephen F. Kingsmore
Center for Pediatric Genomic Medicine, Children’s Mercy Hospitals and Clinics, Kansas City, Missouri, United States of America
Vance G. Fowler Jr
Duke Clinical Research Institute, Durham, North Carolina, United States of America

Corresponding Authors

Competing Interests

The authors have read the journal’s policy and have the following conflicts: CBC and CWW have served as consultants for bioMerieux Inc. ELT, CWW, and GSG received research funding from Novartis Vaccines and Diagnostics, Inc. In the past 12 months, CWW has served as a consultant to Becton, Dickinson and Company, and Gilead Sciences; and has received research or grant support from Cubist Pharmaceuticals, Novartis Pharmaceuticals, and Roche Molecular Diagnostics. ELT is supported by a Veterans Affairs Career Development Award. In the past 12 months, VGF has received grant or research support from Astellas Pharma US, Merck, Theravance, Cerexa, Pfizer, Novartis, MedImmune, Advance Liquid Logic, and the National Institutes of Health; has served as a consultant for Achaogen, Merck, Novartis, Pfizer, NovaDigm Therapeutics, The Medicines Company, Durata Therapeutics, Galderma, and Biosynexus; and is on the Advisory Committee for Cubist Pharmaceuticals. AKZ is a consultant for Covance. EPR receives research support from Agennix AG, Alere Corporation, and National Institutes of Health; and has previously served as a consultant for Agennix AG, Eisai Pharmaceuticals, Idaho Technology, AstraZeneca, Masimo, and Sangard. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SHA ELT DC CBC EPR SFK JL CWW GSG VGF. Performed the experiments: SHA YZ. Analyzed the data: SHA ELT DC JCVV RJL SWG JL VGF. Contributed reagents/materials/analysis tools: CBC AKZ EPR RMO TV SFK JL CWW GSG VGF. Wrote the paper: SHA ELT.