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Research Article

Cholesterol Side-Chain Cleavage Gene Expression in Theca Cells: Augmented Transcriptional Regulation and mRNA Stability in Polycystic Ovary Syndrome

  • Jessica K. Wickenheisser equal contributor,

    equal contributor Contributed equally to this work with: Jessica K. Wickenheisser, Jessica M. Biegler

    Affiliation: Department of Pathology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America

    X
  • Jessica M. Biegler equal contributor,

    equal contributor Contributed equally to this work with: Jessica K. Wickenheisser, Jessica M. Biegler

    Affiliation: Department of Pathology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America

    X
  • Velen L. Nelson-DeGrave,

    Affiliation: Department of Pathology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America

    X
  • Richard S. Legro,

    Affiliation: Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America

    X
  • Jerome F. Strauss III,

    Affiliation: Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia, United States of America

    X
  • Jan M. McAllister mail

    jmcallister@psu.edu

    Affiliations: Department of Pathology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America, Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America

    X
  • Published: November 14, 2012
  • DOI: 10.1371/journal.pone.0048963

About the Authors

Jessica K. Wickenheisser, Jessica M. Biegler, Velen L. Nelson-DeGrave, Jan M. McAllister
Department of Pathology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America
Richard S. Legro, Jan M. McAllister
Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America
Jerome F. Strauss III
Department of Obstetrics and Gynecology, Virginia Commonwealth University, Richmond, Virginia, United States of America

Corresponding Author

Email: jmcallister@psu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JMM VLND JKW. Performed the experiments: JMM VLND JKW JMB. Analyzed the data: JMM VLND JKW JMB. Contributed reagents/materials/analysis tools: JFS RSL JMM. Wrote the paper: JMM VLND JKW JMB RSL JFS.