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Research Article

Lentiviral Transduction of CD34+ Cells Induces Genome-Wide Epigenetic Modifications

  • Yoshiaki Yamagata,

    Affiliations: Inserm, U951, Genethon, Evry, France, Ecole Pratique des Hautes Etudes, UMRS_951, Genethon, Evry, France, Department of Obstetrics and Gynaecology, Yamaguchi University Graduate School of Medicine, Ube, Japan

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  • Véronique Parietti,

    Affiliations: Inserm, U951, Genethon, Evry, France, Ecole Pratique des Hautes Etudes, UMRS_951, Genethon, Evry, France

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  • Daniel Stockholm,

    Affiliations: Inserm, U951, Genethon, Evry, France, Ecole Pratique des Hautes Etudes, UMRS_951, Genethon, Evry, France

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  • Guillaume Corre,

    Affiliations: Inserm, U951, Genethon, Evry, France, Ecole Pratique des Hautes Etudes, UMRS_951, Genethon, Evry, France

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  • Catherine Poinsignon,

    Affiliations: Inserm, U951, Genethon, Evry, France, Université Evry Val d’Essonne, UMRS_951, Genethon, Evry, France

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  • Nizar Touleimat,

    Affiliation: Centre National de Génotypage, CEA – Institut de Génomique, Evry, France

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  • Damien Delafoy,

    Affiliation: Centre National de Génotypage, CEA – Institut de Génomique, Evry, France

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  • Céline Besse,

    Affiliation: Centre National de Génotypage, CEA – Institut de Génomique, Evry, France

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  • Jörg Tost,

    Affiliations: Centre National de Génotypage, CEA – Institut de Génomique, Evry, France, Fondation Jean Dausset- CEPH, Paris, France

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  • Anne Galy mail,

    paldi@genethon.fr (AP); galy@genethon.fr (AG)

    Affiliations: Inserm, U951, Genethon, Evry, France, Ecole Pratique des Hautes Etudes, UMRS_951, Genethon, Evry, France, Université Evry Val d’Essonne, UMRS_951, Genethon, Evry, France

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  • András Paldi mail

    paldi@genethon.fr (AP); galy@genethon.fr (AG)

    Affiliations: Inserm, U951, Genethon, Evry, France, Ecole Pratique des Hautes Etudes, UMRS_951, Genethon, Evry, France

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  • Published: November 07, 2012
  • DOI: 10.1371/journal.pone.0048943

About the Authors

Yoshiaki Yamagata, Véronique Parietti, Daniel Stockholm, Guillaume Corre, Catherine Poinsignon, Anne Galy, András Paldi
Inserm, U951, Genethon, Evry, France
Yoshiaki Yamagata, Véronique Parietti, Daniel Stockholm, Guillaume Corre, Anne Galy, András Paldi
Ecole Pratique des Hautes Etudes, UMRS_951, Genethon, Evry, France
Yoshiaki Yamagata
Department of Obstetrics and Gynaecology, Yamaguchi University Graduate School of Medicine, Ube, Japan
Catherine Poinsignon, Anne Galy
Université Evry Val d’Essonne, UMRS_951, Genethon, Evry, France
Nizar Touleimat, Damien Delafoy, Céline Besse, Jörg Tost
Centre National de Génotypage, CEA – Institut de Génomique, Evry, France
Jörg Tost
Fondation Jean Dausset- CEPH, Paris, France

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: YY AG AP. Performed the experiments: YY VP DS GC CP NT DD CB. Analyzed the data: YY NT DS JT AG AP. Wrote the paper: AP AG.