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Research Article

Neurotensin and CRH Interactions Augment Human Mast Cell Activation

  • Konstantinos–Dionysios Alysandratos equal contributor,

    equal contributor Contributed equally to this work with: Konstantinos–Dionysios Alysandratos, Shahrzad Asadi

    Affiliations: Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, Massachusetts, United States of America, Allergy Clinical Research Center, Allergy Section, Attikon General Hospital, University of Athens Medical School, Athens, Greece, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, United States of America

    Current address: Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

    X
  • Shahrzad Asadi equal contributor,

    equal contributor Contributed equally to this work with: Konstantinos–Dionysios Alysandratos, Shahrzad Asadi

    Affiliations: Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, Massachusetts, United States of America, Department of Pharmacy, Tufts Medical Center, Boston, Massachusetts, United States of America

    X
  • Asimenia Angelidou,

    Affiliations: Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, Massachusetts, United States of America, Allergy Clinical Research Center, Allergy Section, Attikon General Hospital, University of Athens Medical School, Athens, Greece, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, United States of America

    Current address: Department of Pediatrics, University of Texas Southwestern, Children's Medical Center, Dallas, Texas, United States of America

    X
  • Bodi Zhang,

    Affiliations: Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, Massachusetts, United States of America, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, United States of America, Division of Maternal/Fetal Medicine, Department of Obstetrics and Gynecology, Tufts University School of Medicine and Tufts Medical Center, Boston, Massachusetts, United States of America

    X
  • Nikolaos Sismanopoulos,

    Affiliations: Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, Massachusetts, United States of America, Allergy Clinical Research Center, Allergy Section, Attikon General Hospital, University of Athens Medical School, Athens, Greece

    Current address: Department of Internal Medicine, St. Elizabeth's Medical Center, Tufts University, Brighton, Massachusetts, United States of America

    X
  • Hailing Yang,

    Affiliation: Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, Massachusetts, United States of America

    X
  • Agatha Critchfield,

    Affiliation: Division of Maternal/Fetal Medicine, Department of Obstetrics and Gynecology, Tufts University School of Medicine and Tufts Medical Center, Boston, Massachusetts, United States of America

    X
  • Theoharis C. Theoharides mail

    theoharis.theoharides@tufts.edu

    Affiliations: Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, Massachusetts, United States of America, Allergy Clinical Research Center, Allergy Section, Attikon General Hospital, University of Athens Medical School, Athens, Greece, Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, United States of America, Department of Biochemistry, Tufts University School, Boston, Massachusetts, United States of America, Department of Internal Medicine, Tufts University School of Medicine and Tufts Medical Center, Boston, Massachusetts, United States of America, Department of Psychiatry, Tufts University School of Medicine and Tufts Medical Center, Boston, Massachusetts, United States of America

    X
  • Published: November 14, 2012
  • DOI: 10.1371/journal.pone.0048934

About the Authors

Konstantinos–Dionysios Alysandratos, Shahrzad Asadi, Asimenia Angelidou, Bodi Zhang, Nikolaos Sismanopoulos, Hailing Yang, Theoharis C. Theoharides
Molecular Immunopharmacology and Drug Discovery Laboratory, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, Massachusetts, United States of America
Konstantinos–Dionysios Alysandratos, Asimenia Angelidou, Nikolaos Sismanopoulos, Theoharis C. Theoharides
Allergy Clinical Research Center, Allergy Section, Attikon General Hospital, University of Athens Medical School, Athens, Greece
Shahrzad Asadi
Department of Pharmacy, Tufts Medical Center, Boston, Massachusetts, United States of America
Konstantinos–Dionysios Alysandratos, Asimenia Angelidou, Bodi Zhang, Theoharis C. Theoharides
Sackler School of Graduate Biomedical Sciences, Tufts University, Boston, Massachusetts, United States of America
Bodi Zhang, Agatha Critchfield
Division of Maternal/Fetal Medicine, Department of Obstetrics and Gynecology, Tufts University School of Medicine and Tufts Medical Center, Boston, Massachusetts, United States of America
Theoharis C. Theoharides
Department of Biochemistry, Tufts University School, Boston, Massachusetts, United States of America
Theoharis C. Theoharides
Department of Internal Medicine, Tufts University School of Medicine and Tufts Medical Center, Boston, Massachusetts, United States of America
Theoharis C. Theoharides
Department of Psychiatry, Tufts University School of Medicine and Tufts Medical Center, Boston, Massachusetts, United States of America

Corresponding Author

Email: theoharis.theoharides@tufts.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KDA SA AA BZ NS TCT. Performed the experiments: KDA SA AA BZ NS HY. Analyzed the data: KDA SA AA BZ NS TCT. Wrote the paper: KDA SA AA TCT. Provided the human cord blood without identifiers: AC.