Advertisement
Research Article

Osteoclasts in Multiple Myeloma Are Derived from Gr-1+CD11b+Myeloid-Derived Suppressor Cells

  • Junling Zhuang mail,

    zhuangjunling@hotmail.com (JZ); xiangli.yang@vanderbilt.edu (XY)

    Affiliations: Department of Medicine & Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Department of Hematology, Peking Union Medical College Hospital, Beijing, China

    X
  • Jianghong Zhang,

    Affiliation: Department of Medicine & Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

    X
  • Seint T. Lwin,

    Affiliation: Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

    X
  • James R. Edwards,

    Affiliation: Department of Medicine & Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

    X
  • Claire M. Edwards,

    Affiliation: Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

    X
  • Gregory R. Mundy,

    Affiliations: Department of Medicine & Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America, Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America

    X
  • Xiangli Yang mail

    zhuangjunling@hotmail.com (JZ); xiangli.yang@vanderbilt.edu (XY)

    Affiliation: Department of Medicine & Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America

    X
  • Published: November 16, 2012
  • DOI: 10.1371/journal.pone.0048871

About the Authors

Junling Zhuang, Jianghong Zhang, James R. Edwards, Gregory R. Mundy, Xiangli Yang
Department of Medicine & Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
Seint T. Lwin, Claire M. Edwards, Gregory R. Mundy
Department of Cancer Biology, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America
Junling Zhuang
Department of Hematology, Peking Union Medical College Hospital, Beijing, China

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GRM J. Zhuang. Performed the experiments: J. Zhuang J. Zhang JRE STL CME. Analyzed the data: J. Zhuang GRM XY. Contributed reagents/materials/analysis tools: GRM. Wrote the paper: J. Zhuang XY.