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Research Article

Dysregulation of IRP1-Mediated Iron Metabolism Causes Gamma Ray-specific Radioresistance in Leukemia Cells

  • Kurtis J. Haro,

    Affiliations: Molecular Pharmacology and Chemistry Program and Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Weill Cornell Graduate School of Medical Sciences, Department of Pharmacology, New York, New York, United States of America

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  • Aneesh Sheth,

    Affiliations: Molecular Pharmacology and Chemistry Program and Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Weill Cornell Graduate School of Medical Sciences, Department of Pharmacology, New York, New York, United States of America

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  • David A. Scheinberg mail

    d-scheinberg@ski.mskcc.org

    Affiliations: Molecular Pharmacology and Chemistry Program and Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Weill Cornell Graduate School of Medical Sciences, Department of Pharmacology, New York, New York, United States of America

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  • Published: November 14, 2012
  • DOI: 10.1371/journal.pone.0048841

About the Authors

Kurtis J. Haro, Aneesh Sheth, David A. Scheinberg
Molecular Pharmacology and Chemistry Program and Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America
Kurtis J. Haro, Aneesh Sheth, David A. Scheinberg
Weill Cornell Graduate School of Medical Sciences, Department of Pharmacology, New York, New York, United States of America

Corresponding Author

Email: d-scheinberg@ski.mskcc.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KJH DAS. Performed the experiments: KJH AS. Analyzed the data: KJH DAS. Wrote the paper: KJH DAS.