Dysregulation of IRP1-Mediated Iron Metabolism Causes Gamma Ray-specific Radioresistance in Leukemia Cells

Kurtis J. Haro; Aneesh Sheth; David A. Scheinberg

doi:10.1371/journal.pone.0048841

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Peer-reviewed

Research Article

Dysregulation of IRP1-Mediated Iron Metabolism Causes Gamma Ray-specific Radioresistance in Leukemia Cells

Kurtis J. Haro,

Affiliations Molecular Pharmacology and Chemistry Program and Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Weill Cornell Graduate School of Medical Sciences, Department of Pharmacology, New York, New York, United States of America
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Aneesh Sheth,

Affiliations Molecular Pharmacology and Chemistry Program and Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Weill Cornell Graduate School of Medical Sciences, Department of Pharmacology, New York, New York, United States of America
⨯
David A. Scheinberg

* E-mail: d-scheinberg@ski.mskcc.org

Affiliations Molecular Pharmacology and Chemistry Program and Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Weill Cornell Graduate School of Medical Sciences, Department of Pharmacology, New York, New York, United States of America
⨯

Dysregulation of IRP1-Mediated Iron Metabolism Causes Gamma Ray-specific Radioresistance in Leukemia Cells

Kurtis J. Haro,
Aneesh Sheth,
David A. Scheinberg

Published: November 14, 2012
https://doi.org/10.1371/journal.pone.0048841

About the Authors

Kurtis J. Haro

Affiliations Molecular Pharmacology and Chemistry Program and Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, New York, United States of America, Weill Cornell Graduate School of Medical Sciences, Department of Pharmacology, New York, New York, United States of America

Aneesh Sheth

David A. Scheinberg

* E-mail: d-scheinberg@ski.mskcc.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KJH DAS. Performed the experiments: KJH AS. Analyzed the data: KJH DAS. Wrote the paper: KJH DAS.

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Apoptosis
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Gamma rays
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HL60 cells
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Alpha radiation
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Infrared radiation
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DNA repair
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Iron
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Hydrogen peroxide
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