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Research Article

Transcriptional Alterations Related to Neuropathology and Clinical Manifestation of Alzheimer’s Disease

  • Aderbal R. T. Silva,

    Affiliations: Research Center (CIPE), A. C. Camargo Hospital, Sao Paulo, Brazil, Brazilian Brain Bank of the Aging Brain Study Group - Laboratory of Medical Investigations 22 (LIM 22), São Paulo, Brazil

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  • Lea T. Grinberg,

    Affiliations: Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, California, United States of America, Brazilian Brain Bank of the Aging Brain Study Group - Laboratory of Medical Investigations 22 (LIM 22), São Paulo, Brazil

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  • Jose M. Farfel,

    Affiliations: Brazilian Brain Bank of the Aging Brain Study Group - Laboratory of Medical Investigations 22 (LIM 22), São Paulo, Brazil, Division of Geriatrics, Medical School, University of Sao Paulo, Sao Paulo, Brazil

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  • Breno S. Diniz,

    Affiliation: Laboratory of Neuroscience - Laboratory of Medical Investigations 27 (LIM 27) - Department and Institute of Psychiatry, Medical School, University of Sao Paulo, Sao Paulo, Brazil

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  • Leandro A. Lima,

    Affiliation: Research Center (CIPE), A. C. Camargo Hospital, Sao Paulo, Brazil

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  • Paulo J. S. Silva,

    Affiliation: Department of Computer Science, Institute of Mathematics and Statistics, University of Sao Paulo, Sao Paulo, Brazil

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  • Renata E. L. Ferretti,

    Affiliations: Brazilian Brain Bank of the Aging Brain Study Group - Laboratory of Medical Investigations 22 (LIM 22), São Paulo, Brazil, Division of Geriatrics, Medical School, University of Sao Paulo, Sao Paulo, Brazil

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  • Rafael M. Rocha,

    Affiliation: Research Center (CIPE), A. C. Camargo Hospital, Sao Paulo, Brazil

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  • Wilson Jacob Filho,

    Affiliations: Brazilian Brain Bank of the Aging Brain Study Group - Laboratory of Medical Investigations 22 (LIM 22), São Paulo, Brazil, Division of Geriatrics, Medical School, University of Sao Paulo, Sao Paulo, Brazil

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  • Dirce M. Carraro,

    Affiliation: Research Center (CIPE), A. C. Camargo Hospital, Sao Paulo, Brazil

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  • Helena Brentani mail

    helena.brentani@gmail.com

    Affiliation: Laboratory of Clinical Pathology - Laboratory of Medical Investigations 23 (LIM 23), Department and Institute of Psychiatry, Medical School, University of Sao Paulo, Sao Paulo, Brazil

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  • Published: November 07, 2012
  • DOI: 10.1371/journal.pone.0048751

About the Authors

Aderbal R. T. Silva, Leandro A. Lima, Rafael M. Rocha, Dirce M. Carraro
Research Center (CIPE), A. C. Camargo Hospital, Sao Paulo, Brazil
Lea T. Grinberg
Memory and Aging Center, Department of Neurology, University of California San Francisco, San Francisco, California, United States of America
Aderbal R. T. Silva, Lea T. Grinberg, Jose M. Farfel, Renata E. L. Ferretti, Wilson Jacob Filho
Brazilian Brain Bank of the Aging Brain Study Group - Laboratory of Medical Investigations 22 (LIM 22), São Paulo, Brazil
Jose M. Farfel, Renata E. L. Ferretti, Wilson Jacob Filho
Division of Geriatrics, Medical School, University of Sao Paulo, Sao Paulo, Brazil
Breno S. Diniz
Laboratory of Neuroscience - Laboratory of Medical Investigations 27 (LIM 27) - Department and Institute of Psychiatry, Medical School, University of Sao Paulo, Sao Paulo, Brazil
Paulo J. S. Silva
Department of Computer Science, Institute of Mathematics and Statistics, University of Sao Paulo, Sao Paulo, Brazil
Helena Brentani
Laboratory of Clinical Pathology - Laboratory of Medical Investigations 23 (LIM 23), Department and Institute of Psychiatry, Medical School, University of Sao Paulo, Sao Paulo, Brazil

Corresponding Author

Email: helena.brentani@gmail.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HB LG JF BD. Performed the experiments: AS. Analyzed the data: AS LL PS HB. Contributed reagents/materials/analysis tools: RR DC WF RF. Wrote the paper: AS BD HB.