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Research Article

Tmod1 and CP49 Synergize to Control the Fiber Cell Geometry, Transparency, and Mechanical Stiffness of the Mouse Lens

  • David S. Gokhin,

    Affiliation: Department of Cell Biology, The Scripps Research Institute, La Jolla, California, United States of America

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  • Roberta B. Nowak,

    Affiliation: Department of Cell Biology, The Scripps Research Institute, La Jolla, California, United States of America

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  • Nancy E. Kim,

    Affiliation: Department of Cell Biology, The Scripps Research Institute, La Jolla, California, United States of America

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  • Ernest E. Arnett,

    Affiliation: Department of Biological Structure, University of Washington, Seattle, Washington, United States of America

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  • Albert C. Chen,

    Affiliation: Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America

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  • Robert L. Sah,

    Affiliation: Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America

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  • John I. Clark,

    Affiliation: Department of Biological Structure, University of Washington, Seattle, Washington, United States of America

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  • Velia M. Fowler mail

    velia@scripps.edu

    Affiliation: Department of Cell Biology, The Scripps Research Institute, La Jolla, California, United States of America

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  • Published: November 07, 2012
  • DOI: 10.1371/journal.pone.0048734

About the Authors

David S. Gokhin, Roberta B. Nowak, Nancy E. Kim, Velia M. Fowler
Department of Cell Biology, The Scripps Research Institute, La Jolla, California, United States of America
Ernest E. Arnett, John I. Clark
Department of Biological Structure, University of Washington, Seattle, Washington, United States of America
Albert C. Chen, Robert L. Sah
Department of Bioengineering, University of California San Diego, La Jolla, California, United States of America

Corresponding Author

Email: velia@scripps.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RLS JIC VMF. Performed the experiments: DSG RBN NEK EEA ACC. Analyzed the data: DSG RBN NEK VMF. Contributed reagents/materials/analysis tools: DSG RBN NEK EEA ACC RLS JIC VMF. Wrote the paper: DSG VMF.