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Research Article

On the Specificity of Heparin/Heparan Sulfate Binding to Proteins. Anion-Binding Sites on Antithrombin and Thrombin Are Fundamentally Different

  • Philip D. Mosier,
  • Chandravel Krishnasamy,
  • Glen E. Kellogg,
  • Umesh R. Desai mail

    urdesai@vcu.edu

    Affiliation: Department of Medicinal Chemistry and Institute of Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, Virginia, United States of America

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  • Published: November 12, 2012
  • DOI: 10.1371/journal.pone.0048632

About the Authors

Umesh R. Desai
Department of Medicinal Chemistry and Institute of Structural Biology and Drug Discovery, Virginia Commonwealth University, Richmond, Virginia, United States of America

Corresponding Author

Email: urdesai@vcu.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PDM GEK URD. Performed the experiments: PDM CK . Analyzed the data: PDM GEK URD. Contributed reagents/materials/analysis tools: PDM GEK. Wrote the paper: PDM GEK URD.