A Divalent Ion Is Crucial in the Structure and Dominant-Negative Function of ID Proteins, a Class of Helix-Loop-Helix Transcription Regulators

Marie Vivian Wong; Sizun Jiang; Paaventhan Palasingam; Prasanna R. Kolatkar

doi:10.1371/journal.pone.0048591

Loading metrics

Open Access

Peer-reviewed

Research Article

A Divalent Ion Is Crucial in the Structure and Dominant-Negative Function of ID Proteins, a Class of Helix-Loop-Helix Transcription Regulators

Marie Vivian Wong ,

Contributed equally to this work with: Marie Vivian Wong, Sizun Jiang

Affiliations Laboratory for Structural Biochemistry, Genome Institute of Singapore, Singapore, Singapore, Department of Biological Sciences, National University of Singapore, Singapore, Singapore
⨯
Sizun Jiang ,

Contributed equally to this work with: Marie Vivian Wong, Sizun Jiang

Affiliation Laboratory for Structural Biochemistry, Genome Institute of Singapore, Singapore, Singapore
⨯
Paaventhan Palasingam,

Affiliation Laboratory for Structural Biochemistry, Genome Institute of Singapore, Singapore, Singapore
⨯
Prasanna R. Kolatkar

* E-mail: kolatkarp@gis.a-star.edu.sg

Affiliations Laboratory for Structural Biochemistry, Genome Institute of Singapore, Singapore, Singapore, Department of Biological Sciences, National University of Singapore, Singapore, Singapore
⨯

A Divalent Ion Is Crucial in the Structure and Dominant-Negative Function of ID Proteins, a Class of Helix-Loop-Helix Transcription Regulators

Marie Vivian Wong,
Sizun Jiang,
Paaventhan Palasingam,
Prasanna R. Kolatkar

Published: October 30, 2012
https://doi.org/10.1371/journal.pone.0048591

About the Authors

Marie Vivian Wong

Contributed equally to this work with: Marie Vivian Wong, Sizun Jiang

Affiliations Laboratory for Structural Biochemistry, Genome Institute of Singapore, Singapore, Singapore, Department of Biological Sciences, National University of Singapore, Singapore, Singapore

Sizun Jiang

Contributed equally to this work with: Marie Vivian Wong, Sizun Jiang

Affiliation Laboratory for Structural Biochemistry, Genome Institute of Singapore, Singapore, Singapore

Paaventhan Palasingam

Affiliation Laboratory for Structural Biochemistry, Genome Institute of Singapore, Singapore, Singapore

Prasanna R. Kolatkar

* E-mail: kolatkarp@gis.a-star.edu.sg

Affiliations Laboratory for Structural Biochemistry, Genome Institute of Singapore, Singapore, Singapore, Department of Biological Sciences, National University of Singapore, Singapore, Singapore

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MVW SJ PRK. Performed the experiments: MVW SJ. Analyzed the data: SJ MVW PP PRK. Wrote the paper: SJ MVW.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

DNA-binding proteins
Is the Subject Area "DNA-binding proteins" applicable to this article?

Thanks for your feedback.
Electrophoretic mobility shift assay
Is the Subject Area "Electrophoretic mobility shift assay" applicable to this article?

Thanks for your feedback.
Transcription factors
Is the Subject Area "Transcription factors" applicable to this article?

Thanks for your feedback.
Protein structure
Is the Subject Area "Protein structure" applicable to this article?

Thanks for your feedback.
Cloning
Is the Subject Area "Cloning" applicable to this article?

Thanks for your feedback.
Polymerase chain reaction
Is the Subject Area "Polymerase chain reaction" applicable to this article?

Thanks for your feedback.
Cell differentiation
Is the Subject Area "Cell differentiation" applicable to this article?

Thanks for your feedback.
Crystal structure
Is the Subject Area "Crystal structure" applicable to this article?

Thanks for your feedback.