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Research Article

MitoQ Blunts Mitochondrial and Renal Damage during Cold Preservation of Porcine Kidneys

  • Nirmala Parajuli,

    Affiliation: Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

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  • Lia H. Campbell,

    Affiliation: Cell & Tissue Systems, Inc., North Charleston, South Carolina, United States of America

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  • Akira Marine,

    Affiliation: Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

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  • Kelvin G. M. Brockbank,

    Affiliations: Cell & Tissue Systems, Inc., North Charleston, South Carolina, United States of America, Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, United States of America, Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, South Carolina, United States of America

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  • Lee Ann MacMillan-Crow mail

    lmcrow@uams.edu

    Affiliation: Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

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  • Published: November 06, 2012
  • DOI: 10.1371/journal.pone.0048590

About the Authors

Nirmala Parajuli, Akira Marine, Lee Ann MacMillan-Crow
Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America
Lia H. Campbell, Kelvin G. M. Brockbank
Cell & Tissue Systems, Inc., North Charleston, South Carolina, United States of America
Kelvin G. M. Brockbank
Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia, United States of America
Kelvin G. M. Brockbank
Department of Regenerative Medicine and Cell Biology, Medical University of South Carolina, South Carolina, United States of America

Corresponding Author

Email: lmcrow@uams.edu

Competing Interests

Dr. MacMillan-Crow has a Provisional U.S. Patent Application #PCT/US2010/057246– Mito Q Organ cold storage composition and methods of use. PCT filed 11/18/2012, WO 201/063130 A1 published 05/26/2011. Dr. Campbell is an employee and Dr. Brockbank is both an employee and owner of Cell & Tissue Systems, Inc. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: LAMC LHC KGMB. Performed the experiments: NP AM LHC. Analyzed the data: NP LAMC. Wrote the paper: NP AM LHC KGMB LAMC.