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Research Article

Knockdown of Ki-67 by Dicer-Substrate Small Interfering RNA Sensitizes Bladder Cancer Cells to Curcumin-Induced Tumor Inhibition

  • Sivakamasundari Pichu,

    Affiliation: Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Swapna Krishnamoorthy,

    Affiliation: Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Andrei Shishkov,

    Affiliation: Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Bi Zhang,

    Affiliation: Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Peter McCue,

    Affiliation: Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Biddanda C. Ponnappa mail

    Biddanda.Ponnappa@jefferson.edu

    Affiliation: Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

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  • Published: November 12, 2012
  • DOI: 10.1371/journal.pone.0048567

About the Authors

Sivakamasundari Pichu, Swapna Krishnamoorthy, Andrei Shishkov, Bi Zhang, Peter McCue, Biddanda C. Ponnappa
Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, United States of America

Corresponding Author

Email: Biddanda.Ponnappa@jefferson.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BCP AS SP. Performed the experiments: SP SK AS BZ. Analyzed the data: BCP SP SK. Wrote the paper: BCP SP. Provided advice during the course of the research project: PM.