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Research Article

Prostatic Acid Phosphatase Is Required for the Antinociceptive Effects of Thiamine and Benfotiamine

  • Julie K. Hurt,

    Affiliation: Department of Cell and Molecular Physiology, UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, United States of America

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  • Jennifer L. Coleman,

    Affiliation: Department of Cell and Molecular Physiology, UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, United States of America

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  • Brendan J. Fitzpatrick,

    Affiliation: Department of Cell and Molecular Physiology, UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, United States of America

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  • Bonnie Taylor-Blake,

    Affiliation: Department of Cell and Molecular Physiology, UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, United States of America

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  • Arlene S. Bridges,

    Affiliation: Department of Cell and Molecular Physiology, UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, United States of America

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  • Pirkko Vihko,

    Affiliation: Department of Clinical Medicine, Division of Clinical Chemistry, HUSLAB, University of Helsinki, Helsinki, Finland

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  • Mark J. Zylka mail

    zylka@med.unc.edu

    Affiliation: Department of Cell and Molecular Physiology, UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, United States of America

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  • Published: October 31, 2012
  • DOI: 10.1371/journal.pone.0048562

About the Authors

Julie K. Hurt, Jennifer L. Coleman, Brendan J. Fitzpatrick, Bonnie Taylor-Blake, Arlene S. Bridges, Mark J. Zylka
Department of Cell and Molecular Physiology, UNC Neuroscience Center, University of North Carolina at Chapel Hill, Chapel Hill, United States of America
Pirkko Vihko
Department of Clinical Medicine, Division of Clinical Chemistry, HUSLAB, University of Helsinki, Helsinki, Finland

Corresponding Author

Email: zylka@med.unc.edu

Competing Interests

The authors have read the journal's policy and have the following conflicts: M.J.Z. and P.V. are listed as inventors on a patent application (US Patent 2010/0266,569) that was licensed to a commercial entity for the purpose of developing PAP protein as a treatment for pain. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JKH MJZ. Performed the experiments: JKH JLC BJF BTB ASB. Analyzed the data: JKH JLC BJF BTB ASB MJZ. Contributed reagents/materials/analysis tools: PV. Wrote the paper: JKH MJZ.