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Research Article

A Heat-Shock Protein Axis Regulates VEGFR2 Proteolysis, Blood Vessel Development and Repair

  • Alexander F. Bruns,

    Affiliation: Endothelial Cell Biology Unit, School for Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom

    X
  • Nadira Yuldasheva,

    Affiliation: Division of Cardiovascular and Diabetes Research, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom

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  • Antony M. Latham,

    Affiliation: Endothelial Cell Biology Unit, School for Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom

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  • Leyuan Bao,

    Affiliation: Endothelial Cell Biology Unit, School for Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom

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  • Caroline Pellet-Many,

    Affiliation: Centre for Cardiovascular Biology and Medicine, University College London, London, United Kingdom

    X
  • Paul Frankel,

    Affiliation: Centre for Cardiovascular Biology and Medicine, University College London, London, United Kingdom

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  • Sam L. Stephen,

    Affiliation: Endothelial Cell Biology Unit, School for Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom

    X
  • Gareth J. Howell,

    Affiliation: Endothelial Cell Biology Unit, School for Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom

    X
  • Stephen B. Wheatcroft,

    Affiliation: Division of Cardiovascular and Diabetes Research, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom

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  • Mark T. Kearney,

    Affiliation: Division of Cardiovascular and Diabetes Research, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom

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  • Ian C. Zachary,

    Affiliation: Centre for Cardiovascular Biology and Medicine, University College London, London, United Kingdom

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  • Sreenivasan Ponnambalam mail

    s.ponnambalam@leeds.ac.uk

    Affiliation: Endothelial Cell Biology Unit, School for Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom

    X
  • Published: November 06, 2012
  • DOI: 10.1371/journal.pone.0048539

About the Authors

Alexander F. Bruns, Antony M. Latham, Leyuan Bao, Sam L. Stephen, Gareth J. Howell, Sreenivasan Ponnambalam
Endothelial Cell Biology Unit, School for Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom
Nadira Yuldasheva, Stephen B. Wheatcroft, Mark T. Kearney
Division of Cardiovascular and Diabetes Research, Faculty of Medicine and Health, University of Leeds, Leeds, United Kingdom
Caroline Pellet-Many, Paul Frankel, Ian C. Zachary
Centre for Cardiovascular Biology and Medicine, University College London, London, United Kingdom

Corresponding Author

Email: s.ponnambalam@leeds.ac.uk

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AFB SP ICZ NY. Performed the experiments: AFB NY AML LB CPM PF SLS GJH. Analyzed the data: AFB SP. Contributed reagents/materials/analysis tools: SBW MTK ICZ. Wrote the paper: AFB AML SP.