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Research Article

Establishment and Characterization of a Highly Tumourigenic and Cancer Stem Cell Enriched Pancreatic Cancer Cell Line as a Well Defined Model System

  • Johannes Fredebohm mail,

    J.Fredebohm@dkfz-heidelberg.de

    Affiliation: Functional Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany

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  • Michael Boettcher,

    Affiliation: Functional Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany

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  • Christian Eisen,

    Affiliation: Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany

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  • Matthias M. Gaida,

    Affiliation: Institute of Pathology, University Hospital of Heidelberg, Heidelberg, Germany

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  • Anette Heller,

    Affiliation: European Pancreas Center, University Hospital of Heidelberg, Heidelberg, Germany

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  • Shereen Keleg,

    Affiliation: European Pancreas Center, University Hospital of Heidelberg, Heidelberg, Germany

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  • Jörg Tost,

    Affiliation: Institut de Génomique, Centre National de Génotypage, Evry, France

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  • Karin M. Greulich-Bode,

    Affiliation: Genetics of Skin Carcinogenesis, German Cancer Research Center (DKFZ), Heidelberg, Germany

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  • Agnes Hotz-Wagenblatt,

    Affiliation: Functional Proteome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany

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  • Mark Lathrop,

    Affiliation: Institut de Génomique, Centre National de Génotypage, Evry, France

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  • Nathalia A. Giese,

    Affiliation: European Pancreas Center, University Hospital of Heidelberg, Heidelberg, Germany

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  • Jörg D. Hoheisel

    Affiliation: Functional Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany

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  • Published: November 12, 2012
  • DOI: 10.1371/journal.pone.0048503

About the Authors

Johannes Fredebohm, Michael Boettcher, Jörg D. Hoheisel
Functional Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany
Christian Eisen
Stem Cells and Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany
Matthias M. Gaida
Institute of Pathology, University Hospital of Heidelberg, Heidelberg, Germany
Anette Heller, Shereen Keleg, Nathalia A. Giese
European Pancreas Center, University Hospital of Heidelberg, Heidelberg, Germany
Jörg Tost, Mark Lathrop
Institut de Génomique, Centre National de Génotypage, Evry, France
Karin M. Greulich-Bode
Genetics of Skin Carcinogenesis, German Cancer Research Center (DKFZ), Heidelberg, Germany
Agnes Hotz-Wagenblatt
Functional Proteome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany

Corresponding Author

Email: J.Fredebohm@dkfz-heidelberg.de

Competing Interests

Jörg Hoheisel and Jörg Tost serve as editors for PLOS ONE. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials..

Author Contributions

Conceived and designed the experiments: JF JDH MB KMG-B JT AH. Performed the experiments: JF MB KMG-B JT AH CE. Analyzed the data: JF MMG SK ML AH-W NAG AH. Contributed reagents/materials/analysis tools: AH-W NAG AH CE. Wrote the paper: JF JDH.