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Research Article

Liquid Chromatography-Tandem Mass Spectrometry for Analysis of Intestinal Permeability of Loperamide in Physiological Buffer

  • Miriam S. Rubelt mail,

    miriam.heydt@charite.de

    Affiliation: Department of Anesthesiology, Charité, Campus Benjamin Franklin, Berlin, Germany

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  • Salah Amasheh,

    Affiliation: Institute of Clinical Physiology, Charité, Campus Benjamin Franklin, Berlin, Germany

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  • Thomas Grobosch,

    Affiliation: Laboratoriumsmedizin and Toxikologie, Labor Berlin - Charité Vivantes GmbH, Berlin, Germany

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  • Christoph Stein

    Affiliation: Department of Anesthesiology, Charité, Campus Benjamin Franklin, Berlin, Germany

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  • Published: November 08, 2012
  • DOI: 10.1371/journal.pone.0048502

About the Authors

Miriam S. Rubelt, Christoph Stein
Department of Anesthesiology, Charité, Campus Benjamin Franklin, Berlin, Germany
Salah Amasheh
Institute of Clinical Physiology, Charité, Campus Benjamin Franklin, Berlin, Germany
Thomas Grobosch
Laboratoriumsmedizin and Toxikologie, Labor Berlin - Charité Vivantes GmbH, Berlin, Germany

Corresponding Author

Email: miriam.heydt@charite.de

Competing Interests

Dr. Grobosch is employed by Labor Berlin, the Labor Berlin in a subsidiary of the Charité Berlin. This does not alter the authors‚ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: CS SA TG MSR. Performed the experiments: MSR. Analyzed the data: MSR. Contributed reagents/materials/analysis tools: CS SA TG. Wrote the paper: MSR CS SA TG.