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Research Article

MHC Class I-Presented T Cell Epitopes Identified by Immunoproteomics Analysis Are Targets for a Cross Reactive Influenza-Specific T Cell Response

  • James S. Testa,

    Affiliation: Immunotope, Inc., Doylestown, Pennsylvania, United States of America

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  • Vivekananda Shetty,

    Affiliation: Immunotope, Inc., Doylestown, Pennsylvania, United States of America

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  • Julie Hafner,

    Affiliation: Immunotope, Inc., Doylestown, Pennsylvania, United States of America

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  • Zacharie Nickens,

    Affiliation: Immunotope, Inc., Doylestown, Pennsylvania, United States of America

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  • Shivali Kamal,

    Affiliation: Immunotope, Inc., Doylestown, Pennsylvania, United States of America

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  • Gomathinayagam Sinnathamby,

    Affiliation: Immunotope, Inc., Doylestown, Pennsylvania, United States of America

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  • Ramila Philip mail

    rphilip@immunotope.com

    Affiliation: Immunotope, Inc., Doylestown, Pennsylvania, United States of America

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  • Published: November 07, 2012
  • DOI: 10.1371/journal.pone.0048484

About the Authors

James S. Testa, Vivekananda Shetty, Julie Hafner, Zacharie Nickens, Shivali Kamal, Gomathinayagam Sinnathamby, Ramila Philip
Immunotope, Inc., Doylestown, Pennsylvania, United States of America

Corresponding Author

Email: rphilip@immunotope.com

Competing Interests

Provisional United States patent application: #US 61/548,985 Title: MHC class I associated peptides for prevention and treatment of Influenza virus infection. All authors are employed by Immunotope, Inc. There are no further patents, products in development or marketed products to declare. This does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: RP JT VS. Performed the experiments: JT JH ZN GS SK. Analyzed the data: JT VS RP. Wrote the paper: JT VS RP.