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Research Article

Anti-Inflammatory Activity of a Novel Family of Aryl Ureas Compounds in an Endotoxin-Induced Airway Epithelial Cell Injury Model

  • Nuria E. Cabrera-Benitez,

    Affiliations: CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain, Multidisciplinary Organ Dysfunction Evaluation Research Network, Research Unit, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain

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  • Eduardo Pérez-Roth,

    Affiliation: BioLab, Instituto Universitario de Bio-Orgánica “Antonio González” (IUBO-AG), Universidad de La Laguna, La Laguna, Spain

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  • Milena Casula,

    Affiliations: CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain, Multidisciplinary Organ Dysfunction Evaluation Research Network, Research Unit, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain

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  • Ángela Ramos-Nuez,

    Affiliations: CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain, Multidisciplinary Organ Dysfunction Evaluation Research Network, Research Unit, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain

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  • Carla Ríos-Luci,

    Affiliation: BioLab, Instituto Universitario de Bio-Orgánica “Antonio González” (IUBO-AG), Universidad de La Laguna, La Laguna, Spain

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  • Carlos Rodríguez-Gallego,

    Affiliation: Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain

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  • Ithaisa Sologuren,

    Affiliation: Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain

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  • Virginija Jakubkiene,

    Affiliation: Department of Organic Chemistry, Faculty of Chemistry, Vilnius University, Vilnius, Lithuania

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  • Arthur S. Slutsky,

    Affiliations: Keenan Research Center at the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Canada, Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada

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  • José M. Padrón,

    Affiliation: BioLab, Instituto Universitario de Bio-Orgánica “Antonio González” (IUBO-AG), Universidad de La Laguna, La Laguna, Spain

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  • Jesús Villar mail

    jesus.villar54@gmail.com

    Affiliations: CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain, Multidisciplinary Organ Dysfunction Evaluation Research Network, Research Unit, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain, Keenan Research Center at the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Canada

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  • Published: November 08, 2012
  • DOI: 10.1371/journal.pone.0048468

About the Authors

Nuria E. Cabrera-Benitez, Milena Casula, Ángela Ramos-Nuez, Jesús Villar
CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain
Nuria E. Cabrera-Benitez, Milena Casula, Ángela Ramos-Nuez, Jesús Villar
Multidisciplinary Organ Dysfunction Evaluation Research Network, Research Unit, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain
Eduardo Pérez-Roth, Carla Ríos-Luci, José M. Padrón
BioLab, Instituto Universitario de Bio-Orgánica “Antonio González” (IUBO-AG), Universidad de La Laguna, La Laguna, Spain
Carlos Rodríguez-Gallego, Ithaisa Sologuren
Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain
Virginija Jakubkiene
Department of Organic Chemistry, Faculty of Chemistry, Vilnius University, Vilnius, Lithuania
Arthur S. Slutsky, Jesús Villar
Keenan Research Center at the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Canada
Arthur S. Slutsky
Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada

Corresponding Author

Email: jesus.villar54@gmail.com

Competing Interests

JV, JMP, NC, MC, AR, the CIBER de Enfermedades Respiratorias, the Canary Health Service, and the University of La Laguna have filed a patent application related to the use of CKT0103 in sepsis and sepsis-induced ALI. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. The rest of authors have not any conflict of interest to declare.

Author Contributions

Conceived and designed the experiments: JV JMP MC NC. Performed the experiments: MC NC AR CR EP CR VJ JMP IS. Analyzed the data: JV JMP MC NC ASS IS. Contributed reagents/materials/analysis tools: JV JMP NC CRG VJ. Wrote the paper: JV MC NC ASS JMP. Coordinated data collection and data quality: JV JMP MC NC AR ASS. Contributed substantially to the analysis and interpretation of data, provided critical revision of the article, and provided final approval of the version to be published: JV JMP NC EP ASS. Obtained funding for the study: JV JMP. Participated in the writing process of the manuscript and read and approved the final manuscript: NC EP MC AR CRG IS VJ ASS JMP JV.