About the Authors

Nuria E. Cabrera-Benitez

Affiliations CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain, Multidisciplinary Organ Dysfunction Evaluation Research Network, Research Unit, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain

Eduardo Pérez-Roth

Affiliation BioLab, Instituto Universitario de Bio-Orgánica “Antonio González” (IUBO-AG), Universidad de La Laguna, La Laguna, Spain

Milena Casula

Affiliations CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain, Multidisciplinary Organ Dysfunction Evaluation Research Network, Research Unit, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain

Ángela Ramos-Nuez

Affiliations CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain, Multidisciplinary Organ Dysfunction Evaluation Research Network, Research Unit, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain

Carla Ríos-Luci

Affiliation BioLab, Instituto Universitario de Bio-Orgánica “Antonio González” (IUBO-AG), Universidad de La Laguna, La Laguna, Spain

Carlos Rodríguez-Gallego

Affiliation Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain

Ithaisa Sologuren

Affiliation Department of Immunology, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain

Virginija Jakubkiene

Affiliation Department of Organic Chemistry, Faculty of Chemistry, Vilnius University, Vilnius, Lithuania

Arthur S. Slutsky

Affiliations Keenan Research Center at the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Canada, Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, Canada

José M. Padrón

Affiliation BioLab, Instituto Universitario de Bio-Orgánica “Antonio González” (IUBO-AG), Universidad de La Laguna, La Laguna, Spain

Jesús Villar

jesus.villar54@gmail.com

Affiliations CIBER de Enfermedades Respiratorias, Instituto de Salud Carlos III, Madrid, Spain, Multidisciplinary Organ Dysfunction Evaluation Research Network, Research Unit, Hospital Universitario Dr. Negrin, Las Palmas de Gran Canaria, Spain, Keenan Research Center at the Li Ka Shing Knowledge Institute of St. Michael's Hospital, Toronto, Canada

Competing Interests

JV, JMP, NC, MC, AR, the CIBER de Enfermedades Respiratorias, the Canary Health Service, and the University of La Laguna have filed a patent application related to the use of CKT0103 in sepsis and sepsis-induced ALI. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials. The rest of authors have not any conflict of interest to declare.

Author Contributions

Conceived and designed the experiments: JV JMP MC NC. Performed the experiments: MC NC AR CR EP CR VJ JMP IS. Analyzed the data: JV JMP MC NC ASS IS. Contributed reagents/materials/analysis tools: JV JMP NC CRG VJ. Wrote the paper: JV MC NC ASS JMP. Coordinated data collection and data quality: JV JMP MC NC AR ASS. Contributed substantially to the analysis and interpretation of data, provided critical revision of the article, and provided final approval of the version to be published: JV JMP NC EP ASS. Obtained funding for the study: JV JMP. Participated in the writing process of the manuscript and read and approved the final manuscript: NC EP MC AR CRG IS VJ ASS JMP JV.