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Research Article

Targeting COX-2/PGE2 Pathway in HIPK2 Knockdown Cancer Cells: Impact on Dendritic Cell Maturation

  • Alessia Garufi,

    Affiliation: Department of Experimental Oncology, Molecular Oncogenesis Laboratory, Regina Elena National Cancer Institute, Rome, Italy

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  • Giuseppa Pistritto,

    Affiliation: Department of Neuroscience, Section of Pharmacology, University “Tor Vergata”, Rome, Italy

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  • Claudia Ceci,

    Affiliation: Department of Neuroscience, Section of Pharmacology, University “Tor Vergata”, Rome, Italy

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  • Livia Di Renzo,

    Affiliation: Department of Experimental Medicine, Institute Pasteur-Foundation Cenci Bolognetti, “Sapienza” University, Rome, Italy

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  • Roberta Santarelli,

    Affiliation: Department of Experimental Medicine, Institute Pasteur-Foundation Cenci Bolognetti, “Sapienza” University, Rome, Italy

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  • Alberto Faggioni,

    Affiliation: Department of Experimental Medicine, Institute Pasteur-Foundation Cenci Bolognetti, “Sapienza” University, Rome, Italy

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  • Mara Cirone mail,

    gdorazi@unich.it (GD); mara.cirone@uniroma1.it (MC)

    Affiliation: Department of Experimental Medicine, Institute Pasteur-Foundation Cenci Bolognetti, “Sapienza” University, Rome, Italy

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  • Gabriella D’Orazi mail

    gdorazi@unich.it (GD); mara.cirone@uniroma1.it (MC)

    Affiliations: Department of Experimental Oncology, Molecular Oncogenesis Laboratory, Regina Elena National Cancer Institute, Rome, Italy, Department of Medical, Oral and Biotechnological Sciences, University “G. d’Annunzio”, Chieti, Italy

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  • Published: November 07, 2012
  • DOI: 10.1371/journal.pone.0048342

About the Authors

Alessia Garufi, Gabriella D’Orazi
Department of Experimental Oncology, Molecular Oncogenesis Laboratory, Regina Elena National Cancer Institute, Rome, Italy
Giuseppa Pistritto, Claudia Ceci
Department of Neuroscience, Section of Pharmacology, University “Tor Vergata”, Rome, Italy
Livia Di Renzo, Roberta Santarelli, Alberto Faggioni, Mara Cirone
Department of Experimental Medicine, Institute Pasteur-Foundation Cenci Bolognetti, “Sapienza” University, Rome, Italy
Gabriella D’Orazi
Department of Medical, Oral and Biotechnological Sciences, University “G. d’Annunzio”, Chieti, Italy

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: GDO MC. Performed the experiments: AG GP CC LDR RS. Analyzed the data: GDO MC GP LDR. Contributed reagents/materials/analysis tools: AF. Wrote the paper: GDO MC. Critical discussion: AF.