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Research Article

Influenza Virus A/Beijing/501/2009(H1N1) NS1 Interacts with β-Tubulin and Induces Disruption of the Microtubule Network and Apoptosis on A549 Cells

  • Xueqing Han equal contributor,

    equal contributor Contributed equally to this work with: Xueqing Han, Zhihui Li

    Affiliation: Chinese Academy of Inspection and Quarantine, Beijing, China

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  • Zhihui Li equal contributor,

    equal contributor Contributed equally to this work with: Xueqing Han, Zhihui Li

    Affiliation: Chinese Academy of Inspection and Quarantine, Beijing, China

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  • Hongjun Chen,

    Affiliation: Chinese Academy of Inspection and Quarantine, Beijing, China

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  • Huiyu Wang,

    Affiliation: Chinese Academy of Inspection and Quarantine, Beijing, China

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  • Lin Mei,

    Affiliation: Chinese Academy of Inspection and Quarantine, Beijing, China

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  • Shaoqiang Wu,

    Affiliation: Chinese Academy of Inspection and Quarantine, Beijing, China

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  • Tianyi Zhang,

    Affiliation: College of Veterinary Medicine, China Agricultural University, Bejing, China

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  • Bohua Liu mail,

    xiangmei8lin@yahoo.com.cn (XL); bhliuamms@yahoo.com.cn (BL)

    Affiliation: State Key Laboratory of Pathogens and Bio-security, Beijing Institute of Microbiology and Epidemiology, Beijing, China

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  • Xiangmei Lin mail

    xiangmei8lin@yahoo.com.cn (XL); bhliuamms@yahoo.com.cn (BL)

    Affiliation: Chinese Academy of Inspection and Quarantine, Beijing, China

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  • Published: November 06, 2012
  • DOI: 10.1371/journal.pone.0048340

About the Authors

Xueqing Han, Zhihui Li, Hongjun Chen, Huiyu Wang, Lin Mei, Shaoqiang Wu, Xiangmei Lin
Chinese Academy of Inspection and Quarantine, Beijing, China
Bohua Liu
State Key Laboratory of Pathogens and Bio-security, Beijing Institute of Microbiology and Epidemiology, Beijing, China
Tianyi Zhang
College of Veterinary Medicine, China Agricultural University, Bejing, China

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: ZHL XQH BHL XML. Performed the experiments: ZHL XQH HYW LM. Analyzed the data: ZHL XQH SQW BHL XML. Contributed reagents/materials/analysis tools: ZHL HJC LM SQW TYZ. Wrote the paper: ZHL XQH HJC BHL XML.