About the Authors
- Heather J. M. Weir
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Affiliation School of Biochemistry, University of Bristol, Bristol, United Kingdom
- Tracey K. Murray
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Affiliation Neurodegenerative Diseases Drug Hunting Team, Eli Lilly and Co. Ltd., Windlesham, Surrey, United Kingdom
- Patrick G. Kehoe
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Affiliation Dementia Research Group, Institute of Clinical Neurosciences, University of Bristol, Bristol, United Kingdom
- Seth Love
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Affiliation Dementia Research Group, Institute of Clinical Neurosciences, University of Bristol, Bristol, United Kingdom
- Eric M. Verdin
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Affiliation Gladstone Institute of Virology and Immunology, University of California San Francisco, San Francisco, California, United States of America
- Michael J. O’Neill
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Affiliation Neurodegenerative Diseases Drug Hunting Team, Eli Lilly and Co. Ltd., Windlesham, Surrey, United Kingdom
- Jon D. Lane
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* E-mail: nina.balthasar@bristol.ac.uk (NB); jon.lane@bristol.ac.uk (JDL)
Affiliation School of Biochemistry, University of Bristol, Bristol, United Kingdom
- Nina Balthasar
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* E-mail: nina.balthasar@bristol.ac.uk (NB); jon.lane@bristol.ac.uk (JDL)
Affiliation School of Physiology and Pharmacology, University of Bristol, Bristol, United Kingdom
Competing Interests
The authors have read the journal’s policy and have the following competing interest: co-authors TKM and MJO are affiliated with the commercial company “Eli Lilly”, who part-funded HJMW’s Ph.D. studentship. However, for this manuscript, the authors’ collaborators from Eli Lilly simply, in a collaborative manner, provided the PDAPP genetically modified mouse tissues, which the authors processed (blinded) for assessment. This affiliation does not alter the authors’ adherence to all the PLOS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: NB JDL MJO. Performed the experiments: HJMW. Analyzed the data: NB JDL HJMW. Contributed reagents/materials/analysis tools: TKM PGK SL EMV MJO SM. Wrote the paper: NB JDL.