Comparison of Suprachoroidal Drug Delivery with Subconjunctival and Intravitreal Routes Using Noninvasive Fluorophotometry

Puneet Tyagi; Rajendra S. Kadam; Uday B. Kompella

doi:10.1371/journal.pone.0048188

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Open Access

Peer-reviewed

Research Article

Comparison of Suprachoroidal Drug Delivery with Subconjunctival and Intravitreal Routes Using Noninvasive Fluorophotometry

Puneet Tyagi,

Affiliation Nanomedicine and Drug Delivery Laboratory, Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America
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Rajendra S. Kadam,

Affiliation Nanomedicine and Drug Delivery Laboratory, Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯
Uday B. Kompella

* E-mail: uday.kompella@ucdenver.edu

Affiliations Nanomedicine and Drug Delivery Laboratory, Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America, Department of Ophthalmology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America, Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America
⨯

Comparison of Suprachoroidal Drug Delivery with Subconjunctival and Intravitreal Routes Using Noninvasive Fluorophotometry

Puneet Tyagi,
Rajendra S. Kadam,
Uday B. Kompella

Published: October 31, 2012
https://doi.org/10.1371/journal.pone.0048188

About the Authors

Puneet Tyagi

Affiliation Nanomedicine and Drug Delivery Laboratory, Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America

Rajendra S. Kadam

Affiliation Nanomedicine and Drug Delivery Laboratory, Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America

Uday B. Kompella

* E-mail: uday.kompella@ucdenver.edu

Affiliations Nanomedicine and Drug Delivery Laboratory, Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America, Department of Ophthalmology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America, Department of Bioengineering, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PT RK UK. Performed the experiments: PT RK. Analyzed the data: PT RK. Contributed reagents/materials/analysis tools: PT RK UK. Wrote the paper: PT RK UK.

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Eyes
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Choroid
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Drug delivery
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Fluorophotometry
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Pharmacokinetics
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Blood flow
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Animal ocular anatomy
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Routes of administration
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