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Research Article

Catechol-O-Methyltransferase val158met Polymorphism Predicts Placebo Effect in Irritable Bowel Syndrome

  • Kathryn T. Hall mail,

    kthall@bidmc.harvard.edu

    Affiliations: Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America, Program in Placebo Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Anthony J. Lembo,

    Affiliations: Program in Placebo Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America, Department of Gastroenterology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Irving Kirsch,

    Affiliations: Program in Placebo Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America, School of Psychology, University of Plymouth, Devon, United Kingdom

    X
  • Dimitrios C. Ziogas,

    Affiliation: Department of Internal Medicine, University of Athens, Athens, Greece

    X
  • Jeffrey Douaiher,

    Affiliation: Department of Surgery, Johns Hopkins, Baltimore, Maryland, United States of America

    X
  • Karin B. Jensen,

    Affiliations: Program in Placebo Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Lisa A. Conboy,

    Affiliation: Program in Placebo Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • John M. Kelley,

    Affiliations: Program in Placebo Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, Endicott College, Beverly, Massachusetts, United States of America

    X
  • Efi Kokkotou,

    Affiliations: Program in Placebo Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America, Department of Gastroenterology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Ted J. Kaptchuk

    Affiliations: Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America, Program in Placebo Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America

    X
  • Published: October 23, 2012
  • DOI: 10.1371/journal.pone.0048135

About the Authors

Kathryn T. Hall, Ted J. Kaptchuk
Division of General Medicine and Primary Care, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America
Kathryn T. Hall, Anthony J. Lembo, Irving Kirsch, Karin B. Jensen, Lisa A. Conboy, John M. Kelley, Efi Kokkotou, Ted J. Kaptchuk
Program in Placebo Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America
Anthony J. Lembo, Efi Kokkotou
Department of Gastroenterology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, United States of America
Irving Kirsch
School of Psychology, University of Plymouth, Devon, United Kingdom
Dimitrios C. Ziogas
Department of Internal Medicine, University of Athens, Athens, Greece
Jeffrey Douaiher
Department of Surgery, Johns Hopkins, Baltimore, Maryland, United States of America
Karin B. Jensen, John M. Kelley
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America
John M. Kelley
Endicott College, Beverly, Massachusetts, United States of America

Corresponding Author

Email: kthall@bidmc.harvard.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Hypothesis generation: KJ KH TK. Managed genotyping: KH DZ JD. Experimental design: AL KH KJ TK EK KJ. Data analysis: KH AL TK IK JK LC. Manuscript preparation: KH JD TK EK JK IK.