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Research Article

Fasudil Protects the Heart against Ischemia-Reperfusion Injury by Attenuating Endoplasmic Reticulum Stress and Modulating SERCA Activity: The Differential Role for PI3K/Akt and JAK2/STAT3 Signaling Pathways

  • Yapeng Li equal contributor,

    equal contributor Contributed equally to this work with: Yapeng Li, Wei Zhu, Jianping Tao

    Affiliation: Division of Cardiology, Shanghai Sixth Hospital, Shanghai Jiao Tong University School of Medicine, State Key Discipline Division, Shanghai, People's of Republic of China

    X
  • Wei Zhu equal contributor mail,

    equal contributor Contributed equally to this work with: Yapeng Li, Wei Zhu, Jianping Tao

    weizhu65@yahoo.com (WZ); weim.sjtu6h@hotmail.com (MW)

    Affiliation: Division of Cardiology, Shanghai Sixth Hospital, Shanghai Jiao Tong University School of Medicine, State Key Discipline Division, Shanghai, People's of Republic of China

    X
  • Jianping Tao equal contributor,

    equal contributor Contributed equally to this work with: Yapeng Li, Wei Zhu, Jianping Tao

    Affiliation: Division of Cardiology, Shanghai Sixth Hospital, Shanghai Jiao Tong University School of Medicine, State Key Discipline Division, Shanghai, People's of Republic of China

    X
  • Ping Xin,

    Affiliation: Division of Cardiology, Shanghai Sixth Hospital, Shanghai Jiao Tong University School of Medicine, State Key Discipline Division, Shanghai, People's of Republic of China

    X
  • Mingya Liu,

    Affiliation: Division of Cardiology, Shanghai Sixth Hospital, Shanghai Jiao Tong University School of Medicine, State Key Discipline Division, Shanghai, People's of Republic of China

    X
  • Jingbo Li,

    Affiliation: Division of Cardiology, Shanghai Sixth Hospital, Shanghai Jiao Tong University School of Medicine, State Key Discipline Division, Shanghai, People's of Republic of China

    X
  • Meng Wei mail

    weizhu65@yahoo.com (WZ); weim.sjtu6h@hotmail.com (MW)

    Affiliation: Division of Cardiology, Shanghai Sixth Hospital, Shanghai Jiao Tong University School of Medicine, State Key Discipline Division, Shanghai, People's of Republic of China

    X
  • Published: October 31, 2012
  • DOI: 10.1371/journal.pone.0048115

About the Authors

Yapeng Li, Wei Zhu, Jianping Tao, Ping Xin, Mingya Liu, Jingbo Li, Meng Wei
Division of Cardiology, Shanghai Sixth Hospital, Shanghai Jiao Tong University School of Medicine, State Key Discipline Division, Shanghai, People's of Republic of China

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Performed the experiments: YL WZ JT. Analyzed the data: PX ML JL. Wrote the paper: YL WZ MW. Designed the experiment: YL WZ MW. Interpreted the data: YL WZ MW..