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Research Article

Cigarette Smoke Promotes Drug Resistance and Expansion of Cancer Stem Cell-Like Side Population

  • Yi An equal contributor,

    equal contributor Contributed equally to this work with: Yi An, Alan Kiang

    Affiliation: Division of Head and Neck Surgery, Department of Surgery, University of California San Diego, San Diego, California, United States of America

    X
  • Alan Kiang equal contributor,

    equal contributor Contributed equally to this work with: Yi An, Alan Kiang

    Affiliation: Division of Head and Neck Surgery, Department of Surgery, University of California San Diego, San Diego, California, United States of America

    X
  • Jay Patrick Lopez,

    Affiliation: Division of Head and Neck Surgery, Department of Surgery, University of California San Diego, San Diego, California, United States of America

    X
  • Selena Z. Kuo,

    Affiliation: Division of Head and Neck Surgery, Department of Surgery, University of California San Diego, San Diego, California, United States of America

    X
  • Michael Andrew Yu,

    Affiliation: Division of Head and Neck Surgery, Department of Surgery, University of California San Diego, San Diego, California, United States of America

    X
  • Eric L. Abhold,

    Affiliation: Division of Head and Neck Surgery, Department of Surgery, University of California San Diego, San Diego, California, United States of America

    X
  • Jocelyn S. Chen,

    Affiliation: Division of Head and Neck Surgery, Department of Surgery, University of California San Diego, San Diego, California, United States of America

    X
  • Jessica Wang-Rodriguez,

    Affiliation: Department of Pathology, School of Medicine, University of California San Diego, San Diego, California, United States of America

    X
  • Weg M. Ongkeko mail

    rongkeko@ucsd.edu

    Affiliation: Division of Head and Neck Surgery, Department of Surgery, University of California San Diego, San Diego, California, United States of America

    X
  • Published: November 05, 2012
  • DOI: 10.1371/journal.pone.0047919

About the Authors

Yi An, Alan Kiang, Jay Patrick Lopez, Selena Z. Kuo, Michael Andrew Yu, Eric L. Abhold, Jocelyn S. Chen, Weg M. Ongkeko
Division of Head and Neck Surgery, Department of Surgery, University of California San Diego, San Diego, California, United States of America
Jessica Wang-Rodriguez
Department of Pathology, School of Medicine, University of California San Diego, San Diego, California, United States of America

Corresponding Author

Email: rongkeko@ucsd.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: WMO YA AK. Performed the experiments: YA AK JPL MAY ELA JSC SZK. Analyzed the data: WMO YA AK JPL MAY ELA JSC JWR SZK. Contributed reagents/materials/analysis tools: WMO JWR. Wrote the paper: YA AK.