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Research Article

Antibody to Epstein-Barr Virus Deoxyuridine Triphosphate Nucleotidohydrolase and Deoxyribonucleotide Polymerase in a Chronic Fatigue Syndrome Subset

  • A. Martin Lerner mail,

    amartinlerner@yahoo.com

    Affiliation: Department of Medicine, Oakland University William Beaumont School of Medicine, Rochester, Michigan, United States of America

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  • Maria E. Ariza,

    Affiliation: Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America

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  • Marshall Williams,

    Affiliation: Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America

    X
  • Leonard Jason,

    Affiliation: Center for Community Research, DePaul University, Chicago, Illinois, United States of America

    X
  • Safedin Beqaj,

    Affiliation: Pathology Inc, Torrance, California, United States of America

    X
  • James T. Fitzgerald,

    Affiliation: Department of Medical Education, University of Michigan School of Medicine, Ann Arbor, Michigan, United States of America

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  • Stanley Lemeshow,

    Affiliation: College of Public Health, The Ohio State University, Columbus, Ohio, United States of America

    X
  • Ronald Glaser

    Affiliation: Institute for Behavioral Medicine Research, The Ohio State University, Columbus, Ohio, United States of America

    X
  • Published: November 14, 2012
  • DOI: 10.1371/journal.pone.0047891

About the Authors

A. Martin Lerner
Department of Medicine, Oakland University William Beaumont School of Medicine, Rochester, Michigan, United States of America
Maria E. Ariza, Marshall Williams
Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America
Leonard Jason
Center for Community Research, DePaul University, Chicago, Illinois, United States of America
Safedin Beqaj
Pathology Inc, Torrance, California, United States of America
James T. Fitzgerald
Department of Medical Education, University of Michigan School of Medicine, Ann Arbor, Michigan, United States of America
Stanley Lemeshow
College of Public Health, The Ohio State University, Columbus, Ohio, United States of America
Ronald Glaser
Institute for Behavioral Medicine Research, The Ohio State University, Columbus, Ohio, United States of America

Corresponding Author

Email: amartinlerner@yahoo.com

Competing Interests

The authors have read the journal's policy and have the following conflicts. A. Martin Lerner and Safedin Beqaj have ownership of CFS LLC, which owns U.S. patents for diagnosis and treatment of CFS and pending patents distinguishing Groups A and B CFS: PAT. NO. Patent Title 6,894,056 Method for diagnosing and alleviating the symptoms of chronic fatigue syndrome 6,537,997 Method for diagnosing and alleviating the symptoms of chronic fatigue syndrome 6,399,622 Method for diagnosing and alleviating the symptoms of chronic fatigue syndrome 6,258,818 Method for diagnosing and alleviating the symptoms of chronic fatigue syndrome 5,872,123 Method for diagnosing and alleviating the symptoms of chronic fatigue syndrome 5,464,020 Diagnosing and treating subacute cardiac dysfunction 5,357,968 Diagnosing and treating subacute myocarditis 5,213,106 Diagnosing and treating chronic fatigue syndrome by electrocardiographic monitoring of T-waves Pending Methods for diagnosis and treatment of chronic fatigue syndrome Ohio State University and CFS LLC have submitted a patent, EBV DNA polymerase and EBV dUTPase in EBV subset of CFS. Additionally, CFS LLC owns Certificates of Registration issued under the seal of the Copyright Office for the following work: Functional Activity Appraisal Energy Index Score. Health Care Worker Assessment; Quantitative CFS Physical Activity Assessment; Grading Scale for Energy Index Questionnaire. CFS: Based Upon Functional Capacity; EIPS: Energy Index Point Score Chart. A Functional Capacity Measurement Tool for Chronic Fatigue Syndrome (CFS) Patients. Safedin Beqaj is employed by Pathology, Inc. There are no further patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide to authors.

Author Contributions

Conceived and designed the experiments: AL MW LJ SB RG. Performed the experiments: AL MA MW SB RG. Analyzed the data: AL MW JF SL RG. Contributed reagents/materials/analysis tools: AL MA MW LJ SB JF SL RG. Wrote the paper: AL MA MW LJ SB JF SL RG.