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Research Article

Population Genetic Structure and Origins of Native Hawaiians in the Multiethnic Cohort Study

  • Sung K. Kim,

    Affiliations: Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America, Sequenom, Incorporated, San Diego, California, United States of America

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  • Christopher R. Gignoux,

    Affiliation: Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America

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  • Jeffrey D. Wall,

    Affiliation: Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America

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  • Annette Lum-Jones,

    Affiliation: Epidemiology Program, University of Hawai'i Cancer Center, Honolulu, Hawaii, United States of America

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  • Hansong Wang,

    Affiliation: Epidemiology Program, University of Hawai'i Cancer Center, Honolulu, Hawaii, United States of America

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  • Christopher A. Haiman,

    Affiliation: Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Gary K. Chen,

    Affiliation: Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Brian E. Henderson,

    Affiliation: Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Laurence N. Kolonel,

    Affiliation: Epidemiology Program, University of Hawai'i Cancer Center, Honolulu, Hawaii, United States of America

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  • Loic Le Marchand,

    Affiliation: Epidemiology Program, University of Hawai'i Cancer Center, Honolulu, Hawaii, United States of America

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  • Daniel O. Stram,

    Affiliation: Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America

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  • Richa Saxena,

    Affiliations: Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America, Center for Human Genetics Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America

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  • Iona Cheng mail

    icheng@cc.hawaii.edu

    Affiliation: Epidemiology Program, University of Hawai'i Cancer Center, Honolulu, Hawaii, United States of America

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  • Published: November 07, 2012
  • DOI: 10.1371/journal.pone.0047881

About the Authors

Sung K. Kim, Christopher R. Gignoux, Jeffrey D. Wall
Institute for Human Genetics, University of California San Francisco, San Francisco, California, United States of America
Sung K. Kim
Sequenom, Incorporated, San Diego, California, United States of America
Annette Lum-Jones, Hansong Wang, Laurence N. Kolonel, Loic Le Marchand, Iona Cheng
Epidemiology Program, University of Hawai'i Cancer Center, Honolulu, Hawaii, United States of America
Christopher A. Haiman, Gary K. Chen, Brian E. Henderson, Daniel O. Stram
Department of Preventive Medicine, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, California, United States of America
Richa Saxena
Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America
Richa Saxena
Center for Human Genetics Research, Massachusetts General Hospital, Boston, Massachusetts, United States of America

Corresponding Author

Email: icheng@cc.hawaii.edu

Competing Interests

The authors declare that the author, Sung Kim, is employed by Sequenom, Inc. This does not alter the authors‚ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: SKK CRG JDW ALJ CAH RS IC. Performed the experiments: SKK ALJ. Analyzed the data: SKK CRG ALJ GKC. Contributed reagents/materials/analysis tools: SKK CRG GKC. Wrote the paper: SKK CRG JDW ALJ HW CAH GKC BEH LNK LLM DOS RS IC.