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Research Article

Staphylococcus aureus Proteins Sbi and Efb Recruit Human Plasmin to Degrade Complement C3 and C3b

  • Tina K. Koch,

    Affiliation: Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection, Biology, Jena, Germany

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  • Michael Reuter,

    Affiliation: Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection, Biology, Jena, Germany

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  • Diana Barthel,

    Affiliation: Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection, Biology, Jena, Germany

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  • Sascha Böhm,

    Affiliation: Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection, Biology, Jena, Germany

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  • Jean van den Elsen,

    Affiliation: University of Bath, Bath, United Kingdom

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  • Peter Kraiczy,

    Affiliation: Institute of Medical Microbiology and Infection Control, University Hospital Frankfurt, Germany

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  • Peter F. Zipfel,

    Affiliations: Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection, Biology, Jena, Germany, Friedrich Schiller University Jena, Germany

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  • Christine Skerka mail

    christine.skerka@hki-jena.de

    Affiliation: Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection, Biology, Jena, Germany

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  • Published: October 11, 2012
  • DOI: 10.1371/journal.pone.0047638

About the Authors

Tina K. Koch, Michael Reuter, Diana Barthel, Sascha Böhm, Peter F. Zipfel, Christine Skerka
Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection, Biology, Jena, Germany
Jean van den Elsen
University of Bath, Bath, United Kingdom
Peter Kraiczy
Institute of Medical Microbiology and Infection Control, University Hospital Frankfurt, Germany
Peter F. Zipfel
Friedrich Schiller University Jena, Germany

Corresponding Author

Email: christine.skerka@hki-jena.de

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CS TKK. Performed the experiments: TKK MR DB SB. Analyzed the data: TKK MR DB SB JvdE PFZ PK CS. Contributed reagents/materials/analysis tools: DB PK SB. Wrote the paper: TKK PFZ CS.