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Research Article

Quercetin Inhibits Angiogenesis Mediated Human Prostate Tumor Growth by Targeting VEGFR- 2 Regulated AKT/mTOR/P70S6K Signaling Pathways

  • Poyil Pratheeshkumar,

    Affiliation: Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America

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  • Amit Budhraja,

    Affiliation: Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America

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  • Young-Ok Son,

    Affiliation: Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America

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  • Xin Wang,

    Affiliation: Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America

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  • Zhuo Zhang,

    Affiliation: Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America

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  • Songze Ding,

    Affiliation: Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America

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  • Lei Wang,

    Affiliation: Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America

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  • Andrew Hitron,

    Affiliation: Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America

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  • Jeong-Chae Lee,

    Affiliation: Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America

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  • Mei Xu,

    Affiliation: Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America

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  • Gang Chen,

    Affiliation: Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America

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  • Jia Luo,

    Affiliation: Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America

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  • Xianglin Shi mail

    xshi5@email.uky.edu

    Affiliation: Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America

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  • Published: October 18, 2012
  • DOI: 10.1371/journal.pone.0047516

About the Authors

Poyil Pratheeshkumar, Amit Budhraja, Young-Ok Son, Xin Wang, Zhuo Zhang, Songze Ding, Lei Wang, Andrew Hitron, Jeong-Chae Lee, Xianglin Shi
Graduate Center for Toxicology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America
Mei Xu, Gang Chen, Jia Luo
Department of Internal Medicine, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America

Corresponding Author

Email: xshi5@email.uky.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PP XS. Performed the experiments: PP. Analyzed the data: PP XS. Contributed reagents/materials/analysis tools: PP AB YOS XW ZZ SD LW AH JCL MX GC JL XS. Wrote the paper: PP.