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Research Article

In Vitro and Ex Vivo Inhibition of Human Telomerase by Anti-HIV Nucleoside Reverse Transcriptase Inhibitors (NRTIs) but Not by Non-NRTIs

  • Kyle R. Hukezalie,

    Affiliations: Genetics Graduate Program, The University of British Columbia, Vancouver, British Columbia, Canada, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada

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  • Naresh R. Thumati,

    Affiliation: Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada

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  • Hélène C. F. Côté,

    Affiliations: Genetics Graduate Program, The University of British Columbia, Vancouver, British Columbia, Canada, Department of Pathology and Laboratory Medicine (HCFC), The University of British Columbia, Vancouver, British Columbia, Canada

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  • Judy M. Y. Wong mail

    judy.wong@ubc.ca

    Affiliations: Genetics Graduate Program, The University of British Columbia, Vancouver, British Columbia, Canada, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada

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  • Published: November 15, 2012
  • DOI: 10.1371/journal.pone.0047505

About the Authors

Kyle R. Hukezalie, Hélène C. F. Côté, Judy M. Y. Wong
Genetics Graduate Program, The University of British Columbia, Vancouver, British Columbia, Canada
Kyle R. Hukezalie, Naresh R. Thumati, Judy M. Y. Wong
Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada
Hélène C. F. Côté
Department of Pathology and Laboratory Medicine (HCFC), The University of British Columbia, Vancouver, British Columbia, Canada

Corresponding Author

Email: judy.wong@ubc.ca

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: JMYW KRH HCFC. Performed the experiments: KRH NRT. Analyzed the data: KH NRT JMYW. Contributed reagents/materials/analysis tools: KH NRT. Wrote the paper: KH HCFC JMYW.