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Research Article

Dioscorea alata Attenuates Renal Interstitial Cellular Fibrosis by Regulating Smad- and Epithelial-Mesenchymal Transition Signaling Pathways

  • Shu-Fen Liu,

    Affiliation: Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

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  • Shan-Yu Chang,

    Affiliation: Department of Graduate Institute of Biomedical Science, Chung Hwa University of Medical Technology, Tainan, Taiwan

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  • Tao-Chen Lee,

    Affiliation: Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan

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  • Lea-Yea Chuang,

    Affiliation: Department of Biochemistry, Kaohsiung Medical University, Kaohsiung, Taiwan

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  • Jinn-Yuh Guh,

    Affiliation: Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

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  • Chien-Ya Hung,

    Affiliation: Department of Food Nutrition Chung Hwa University of Medical Technology, Tainan, Taiwan

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  • Tsung-Jen Hung,

    Affiliation: Department of Graduate Institute of Biomedical Science, Chung Hwa University of Medical Technology, Tainan, Taiwan

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  • Yu-Ju Hung,

    Affiliation: Department of Public Health, National Taiwan University, Taipei, Taiwan

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  • Po-Yi Chen,

    Affiliation: Department of Optometry, Chung Hwa University of Medical Technology, Tainan, Taiwan

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  • Pei-fang Hsieh,

    Affiliation: Department of Graduate Institute of Biomedical Science, Chung Hwa University of Medical Technology, Tainan, Taiwan

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  • Yu-Lin Yang mail

    call0955443221@gmail.com

    Affiliations: Department of Graduate Institute of Biomedical Science, Chung Hwa University of Medical Technology, Tainan, Taiwan, Department of Medical Laboratory Science and Biotechnology, Chung Hwa University of Medical Technology, Tainan, Taiwan

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  • Published: November 08, 2012
  • DOI: 10.1371/journal.pone.0047482

About the Authors

Shu-Fen Liu, Jinn-Yuh Guh
Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Shan-Yu Chang, Tsung-Jen Hung, Pei-fang Hsieh, Yu-Lin Yang
Department of Graduate Institute of Biomedical Science, Chung Hwa University of Medical Technology, Tainan, Taiwan
Tao-Chen Lee
Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan
Lea-Yea Chuang
Department of Biochemistry, Kaohsiung Medical University, Kaohsiung, Taiwan
Chien-Ya Hung
Department of Food Nutrition Chung Hwa University of Medical Technology, Tainan, Taiwan
Yu-Ju Hung
Department of Public Health, National Taiwan University, Taipei, Taiwan
Po-Yi Chen
Department of Optometry, Chung Hwa University of Medical Technology, Tainan, Taiwan
Yu-Lin Yang
Department of Medical Laboratory Science and Biotechnology, Chung Hwa University of Medical Technology, Tainan, Taiwan

Corresponding Author

Email: call0955443221@gmail.com

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: TJH TCL PYC YJH YLY SFL LYC JYG. Performed the experiments: TJH TCL PYC YJH YLY SFL SYC CYH. Analyzed the data: TJH TCL PYC YJH YLY SFL SYC LYC JYG CYH. Contributed reagents/materials/analysis tools: TCL YLY SFL. Wrote the paper: TCL YLY SFL SYC PFH.