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Research Article

Targeted Disruption in Mice of a Neural Stem Cell-Maintaining, KRAB-Zn Finger-Encoding Gene That Has Rapidly Evolved in the Human Lineage

  • Huan-Chieh Chien equal contributor,

    equal contributor Contributed equally to this work with: Huan-Chieh Chien, Hurng-Yi Wang, Yi-Ning Su

    Affiliations: Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan, Republic of China, Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, Republic of China

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  • Hurng-Yi Wang equal contributor,

    equal contributor Contributed equally to this work with: Huan-Chieh Chien, Hurng-Yi Wang, Yi-Ning Su

    Affiliation: Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China

    X
  • Yi-Ning Su equal contributor,

    equal contributor Contributed equally to this work with: Huan-Chieh Chien, Hurng-Yi Wang, Yi-Ning Su

    Affiliation: Department of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan, Republic of China

    X
  • Kuan-Yu Lai,

    Affiliation: Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, Republic of China

    X
  • Li-Chen Lu,

    Affiliation: Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, Republic of China

    X
  • Pau-Chung Chen,

    Affiliation: Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan, Republic of China

    X
  • Shih-Feng Tsai,

    Affiliation: Division of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli County, Taiwan, Republic of China

    X
  • Chung-I Wu,

    Affiliation: Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America

    X
  • Wu-Shiun Hsieh,

    Affiliation: Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China

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  • Che-Kun James Shen mail

    ckshen@imb.sinica.edu.tw

    Affiliations: Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan, Republic of China, Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, Republic of China

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  • Published: October 10, 2012
  • DOI: 10.1371/journal.pone.0047481

About the Authors

Huan-Chieh Chien, Che-Kun James Shen
Department of Life Sciences and Institute of Genome Sciences, National Yang-Ming University, Taipei, Taiwan, Republic of China
Huan-Chieh Chien, Kuan-Yu Lai, Li-Chen Lu, Che-Kun James Shen
Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan, Republic of China
Hurng-Yi Wang
Institute of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China
Yi-Ning Su
Department of Medical Genetics, National Taiwan University Hospital, Taipei, Taiwan, Republic of China
Pau-Chung Chen
Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan, Republic of China
Shih-Feng Tsai
Division of Molecular and Genomic Medicine, National Health Research Institutes, Zhunan, Miaoli County, Taiwan, Republic of China
Chung-I Wu
Department of Ecology and Evolution, University of Chicago, Chicago, Illinois, United States of America
Wu-Shiun Hsieh
Department of Pediatrics, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan, Republic of China

Corresponding Author

Email: ckshen@imb.sinica.edu.tw

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: HCC HYW WSH CKJS. Performed the experiments: HCC HYW YNS KYL LCL PCC. Analyzed the data: HCC HYW WSH CKJS. Contributed reagents/materials/analysis tools: SFT CIW WSH. Wrote the paper: HCC HYW CKJS.