DCM-Related Tropomyosin Mutants E40K/E54K Over-Inhibit the Actomyosin Interaction and Lead to a Decrease in the Number of Cycling Cross-Bridges

Fan Bai; Heather L. Groth; Masataka Kawai

doi:10.1371/journal.pone.0047471

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Open Access

Peer-reviewed

Research Article

DCM-Related Tropomyosin Mutants E40K/E54K Over-Inhibit the Actomyosin Interaction and Lead to a Decrease in the Number of Cycling Cross-Bridges

Fan Bai,

Affiliation Departments of Anatomy and Cell Biology, and Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Heather L. Groth,

Affiliation Departments of Anatomy and Cell Biology, and Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯
Masataka Kawai

* E-mail: masataka-kawai@uiowa.edu

Affiliation Departments of Anatomy and Cell Biology, and Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America
⨯

DCM-Related Tropomyosin Mutants E40K/E54K Over-Inhibit the Actomyosin Interaction and Lead to a Decrease in the Number of Cycling Cross-Bridges

Fan Bai,
Heather L. Groth,
Masataka Kawai

Published: October 15, 2012
https://doi.org/10.1371/journal.pone.0047471

About the Authors

Fan Bai

Affiliation Departments of Anatomy and Cell Biology, and Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America

Heather L. Groth

Affiliation Departments of Anatomy and Cell Biology, and Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America

Masataka Kawai

* E-mail: masataka-kawai@uiowa.edu

Affiliation Departments of Anatomy and Cell Biology, and Internal Medicine, University of Iowa, Iowa City, Iowa, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MK FB. Performed the experiments: FB HLG. Analyzed the data: HLG FB MK. Contributed reagents/materials/analysis tools: MK. Wrote the paper: MK FB.

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