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Research Article

Functional Assessment of Human Coding Mutations Affecting Skin Pigmentation Using Zebrafish

  • Zurab R. Tsetskhladze mail,

    zut555@gmail.com (ZRT); kcheng76@gmail.com (KCC)

    Affiliations: Jake Gittlen Cancer Research Foundation, Penn State Hershey College of Medicine, Hershey, Pennsylvania, United States of America, Division of Experimental Pathology, Department of Pathology, Penn State Hershey College of Medicine, Hershey, Pennsylvania, United States of America

    X
  • Victor A. Canfield,

    Affiliation: Department of Pharmacology, Penn State Hershey College of Medicine, Hershey, Pennsylvania, United States of America

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  • Khai C. Ang,

    Affiliations: Jake Gittlen Cancer Research Foundation, Penn State Hershey College of Medicine, Hershey, Pennsylvania, United States of America, Division of Experimental Pathology, Department of Pathology, Penn State Hershey College of Medicine, Hershey, Pennsylvania, United States of America

    X
  • Steven M. Wentzel,

    Affiliations: Jake Gittlen Cancer Research Foundation, Penn State Hershey College of Medicine, Hershey, Pennsylvania, United States of America, Division of Experimental Pathology, Department of Pathology, Penn State Hershey College of Medicine, Hershey, Pennsylvania, United States of America

    X
  • Katherine P. Reid,

    Affiliations: Jake Gittlen Cancer Research Foundation, Penn State Hershey College of Medicine, Hershey, Pennsylvania, United States of America, Division of Experimental Pathology, Department of Pathology, Penn State Hershey College of Medicine, Hershey, Pennsylvania, United States of America

    X
  • Arthur S. Berg,

    Affiliation: Department of Public Health Sciences, Penn State Hershey College of Medicine, Hershey, Pennsylvania, United States of America

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  • Stephen L. Johnson,

    Affiliation: Department of Genetics, Washington University Medical School, St. Louis, Missouri, United States of America

    X
  • Koichi Kawakami,

    Affiliation: Division of Molecular and Developmental Biology, National Institute of Genetics, Department of Genetics, Graduate University for Advanced Studies (Sokendai), Mishima, Shizuoka, Japan

    X
  • Keith C. Cheng mail

    zut555@gmail.com (ZRT); kcheng76@gmail.com (KCC)

    Affiliations: Jake Gittlen Cancer Research Foundation, Penn State Hershey College of Medicine, Hershey, Pennsylvania, United States of America, Division of Experimental Pathology, Department of Pathology, Penn State Hershey College of Medicine, Hershey, Pennsylvania, United States of America

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  • Published: October 10, 2012
  • DOI: 10.1371/journal.pone.0047398

About the Authors

Zurab R. Tsetskhladze, Khai C. Ang, Steven M. Wentzel, Katherine P. Reid, Keith C. Cheng
Jake Gittlen Cancer Research Foundation, Penn State Hershey College of Medicine, Hershey, Pennsylvania, United States of America
Victor A. Canfield
Department of Pharmacology, Penn State Hershey College of Medicine, Hershey, Pennsylvania, United States of America
Arthur S. Berg
Department of Public Health Sciences, Penn State Hershey College of Medicine, Hershey, Pennsylvania, United States of America
Stephen L. Johnson
Department of Genetics, Washington University Medical School, St. Louis, Missouri, United States of America
Koichi Kawakami
Division of Molecular and Developmental Biology, National Institute of Genetics, Department of Genetics, Graduate University for Advanced Studies (Sokendai), Mishima, Shizuoka, Japan
Zurab R. Tsetskhladze, Khai C. Ang, Steven M. Wentzel, Katherine P. Reid, Keith C. Cheng
Division of Experimental Pathology, Department of Pathology, Penn State Hershey College of Medicine, Hershey, Pennsylvania, United States of America

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: KCC VAC ZRT. Performed the experiments: ZRT KCA KPR SMW. Analyzed the data: KCC ZRT VAC KCA SMW ASB. Contributed reagents/materials/analysis tools: KCC SLJ KK. Wrote the paper: ZRT KCC KPR.