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Research Article

A Genome-Wide Association Study of Circulating Galectin-3

  • Rudolf A. de Boer equal contributor,

    equal contributor Contributed equally to this work with: Rudolf A. de Boer, Niek Verweij, Irene Mateo Leach, Pim van der Harst

    Affiliation: Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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  • Niek Verweij equal contributor,

    equal contributor Contributed equally to this work with: Rudolf A. de Boer, Niek Verweij, Irene Mateo Leach, Pim van der Harst

    Affiliation: Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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  • Dirk J. van Veldhuisen,

    Affiliation: Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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  • Harm-Jan Westra,

    Affiliation: Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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  • Stephan J. L. Bakker,

    Affiliation: Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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  • Ron T. Gansevoort,

    Affiliation: Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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  • Anneke C. Muller Kobold,

    Affiliation: Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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  • Wiek H. van Gilst,

    Affiliation: Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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  • Lude Franke,

    Affiliation: Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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  • Irene Mateo Leach equal contributor,

    equal contributor Contributed equally to this work with: Rudolf A. de Boer, Niek Verweij, Irene Mateo Leach, Pim van der Harst

    Affiliation: Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands

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  • Pim van der Harst equal contributor mail

    equal contributor Contributed equally to this work with: Rudolf A. de Boer, Niek Verweij, Irene Mateo Leach, Pim van der Harst

    p.van.der.harst@umcg.nl

    Affiliations: Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands, Durrer Center, Utrecht, The Netherlands

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  • Published: October 09, 2012
  • DOI: 10.1371/journal.pone.0047385

About the Authors

Rudolf A. de Boer, Niek Verweij, Dirk J. van Veldhuisen, Wiek H. van Gilst, Irene Mateo Leach, Pim van der Harst
Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
Harm-Jan Westra, Lude Franke, Pim van der Harst
Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
Stephan J. L. Bakker, Ron T. Gansevoort
Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
Anneke C. Muller Kobold
Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
Pim van der Harst
Durrer Center, Utrecht, The Netherlands

Corresponding Author

Email: p.van.der.harst@umcg.nl

Competing Interests

We have read the journal's policy and have the following potential conflicts of interest: BG Medicine, Inc., has certain rights related to galectin-3 measurements. BG Medicine Inc. provided an unrestricted research grant to the Department of Cardiology of the University Medical Centre Groningen. Drs. R.A. de Boer and D.J. van Veldhuisen have received consulting and speaker's fees from BG Medicine, Inc.

Author Contributions

Conceived and designed the experiments: RAdB NV IML PvdH. Performed the experiments: RAdB NV HJW SJLB ACMK LF IML PvdH. Analyzed the data: RAdB NV HJW SJLB ACMK LF IML PvdH. Contributed reagents/materials/analysis tools: RAdB NV DJvV HJW SJLB RTG ACMK WHvG LF IML PvdH. Wrote the paper: RAdB NV IML PvdH. Read and commented on the earlier drafts of this manuscript: RAdB NV DJvV HJW SJLB RTG ACMK WHvG LF IML PvdH.