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Research Article

Fusion Toxin BLyS-Gelonin Inhibits Growth of Malignant Human B Cell Lines In Vitro and In Vivo

  • Troy A. Luster,

    Affiliation: Department of Oncology Research, Human Genome Sciences, Inc., Rockville, Maryland, United States of America

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  • Ipsita Mukherjee,

    Affiliation: Department of Oncology Research, Human Genome Sciences, Inc., Rockville, Maryland, United States of America

    X
  • Jeffrey A. Carrell,

    Affiliation: Department of Lead Development, Human Genome Sciences, Inc., Rockville, Maryland, United States of America

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  • Yun Hee Cho,

    Affiliation: Department of Lead Development, Human Genome Sciences, Inc., Rockville, Maryland, United States of America

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  • Jeffrey Gill,

    Affiliation: Department of Lead Development, Human Genome Sciences, Inc., Rockville, Maryland, United States of America

    X
  • Lizbeth Kelly,

    Affiliation: Department of Immunology Research, Human Genome Sciences, Inc., Rockville, Maryland, United States of America

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  • Andy Garcia,

    Affiliation: Department of Lead Development, Human Genome Sciences, Inc., Rockville, Maryland, United States of America

    X
  • Christopher Ward,

    Affiliation: Department of Lead Development, Human Genome Sciences, Inc., Rockville, Maryland, United States of America

    X
  • Luke Oh,

    Affiliation: Department of Immunology Research, Human Genome Sciences, Inc., Rockville, Maryland, United States of America

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  • Stephen J. Ullrich,

    Affiliation: Department of Lead Development, Human Genome Sciences, Inc., Rockville, Maryland, United States of America

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  • Thi-Sau Migone,

    Affiliation: Department of Immunology Research, Human Genome Sciences, Inc., Rockville, Maryland, United States of America

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  • Robin Humphreys mail

    robin_humphreys@hgsi.com

    Affiliation: Department of Oncology Research, Human Genome Sciences, Inc., Rockville, Maryland, United States of America

    X
  • Published: October 09, 2012
  • DOI: 10.1371/journal.pone.0047361

About the Authors

Troy A. Luster, Ipsita Mukherjee, Robin Humphreys
Department of Oncology Research, Human Genome Sciences, Inc., Rockville, Maryland, United States of America
Jeffrey A. Carrell, Yun Hee Cho, Jeffrey Gill, Andy Garcia, Christopher Ward, Stephen J. Ullrich
Department of Lead Development, Human Genome Sciences, Inc., Rockville, Maryland, United States of America
Lizbeth Kelly, Luke Oh, Thi-Sau Migone
Department of Immunology Research, Human Genome Sciences, Inc., Rockville, Maryland, United States of America

Corresponding Author

Email: robin_humphreys@hgsi.com

Competing Interests

The authors have read the journal's competing interests policy and have the following financial conflicts: All authors are current or former employees and stock holders of Human Genome Sciences. HGS owns several granted and pending patents directed to isolated BLyS polypeptides and BLyS-toxin fusion, details of which will be made available on request. None of the listed authors on the manuscript are inventors on the above-referenced patents. These disclosures do not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: TAL YHC TSM RH. Performed the experiments: TAL IM JAC YHC JG LK AG CW. Analyzed the data: TAL IM SJU TSM RH LO. Wrote the paper: TAL JAC YHC AC.