About the Authors

Eduardo Díaz-Rubio

ediazrubio.hcsc@salud.madrid.org

Affiliation Department of Medical Oncology, Hospital Clínico San Carlos (HCSC), Red Temática de Investigación Cooperativa en Cáncer (RD06/0020/0021), Facultad de Medicina, Universidad Complutense, Instituto de Investigación Sanitaria del HCSC (IdISSC), Madrid, Spain

Auxiliadora Gómez-España

Affiliation Department of Medical Oncology, Hospital Reina Sofía, Córdoba, Spain

Bartomeu Massutí

Affiliation Department of Medical Oncology, Hospital General, Alicante, Spain

Javier Sastre

Affiliation Department of Medical Oncology, Hospital Clínico San Carlos (HCSC), Red Temática de Investigación Cooperativa en Cáncer (RD06/0020/0021), Facultad de Medicina, Universidad Complutense, Instituto de Investigación Sanitaria del HCSC (IdISSC), Madrid, Spain

Margarita Reboredo

Affiliation Department of Medical Oncology, Complejo Hospitalario Universitario La Coruña, La Coruña, Spain

José Luis Manzano

Affiliation Department of Medical Oncology, Instituto Catalán de Oncología, Hospital Germans Trias I Pujol, Badalona, Spain

Fernando Rivera

Affiliation Department of Medical Oncology, Hospital Marqués de Valdecilla, Santander, Spain

MªJosé Safont

Affiliation Department of Medical Oncology, Hospital General de Valencia, Valencia, Spain

Clara Montagut

Affiliation Department of Medical Oncology, Hospital del Mar, Barcelona, Spain

Encarnación González

Affiliation Department of Medical Oncology, Hospital Virgen de las Nieves, Granada, Spain

Manuel Benavides

Affiliation Department of Medical Oncology, Hospital Universitario Carlos Haya, Málaga, Spain

Eugenio Marcuello

Affiliation Department of Medical Oncology, Hospital Santa Creu i Sant Pau, Barcelona, Spain

Andrés Cervantes

Affiliation Department of Medical Oncology, Institute of Health Research INCLIVA. University of Valencia, Valencia, Spain

Purificación Martínez de Prado

Affiliation Department of Medical Oncology, Hospital de Basurto, Vizcaya, Spain

Carlos Fernández-Martos

Affiliation Department of Medical Oncology, Instituto Valenciano de Oncología, Valencia, Spain

Antonio Arrivi

Affiliation Department of Medical Oncology, Fundación Hospital Son Llatzer, Palma de Mallorca, Spain

Inmaculada Bando

Affiliation Department of Medical Oncology, Hospital Clínico San Carlos (HCSC), Red Temática de Investigación Cooperativa en Cáncer (RD06/0020/0021), Facultad de Medicina, Universidad Complutense, Instituto de Investigación Sanitaria del HCSC (IdISSC), Madrid, Spain

Enrique Aranda

Membership of the Spanish Cooperative Group for the Treatment of Digestive Tumors (TTD) is provided in the Acknowledgments

Affiliation Department of Medical Oncology, Hospital Reina Sofía, Córdoba, Spain

Competing Interests

Eduardo Díaz-Rubio: Consultant or advisory role: Roche and Research Funding: Roche Enrique Aranda: Consultant or Advisory Role: Roche and Merck Serono Javier Sastre: Consultant or Advisory Role: Roche Andrés Cervantes. Consultant or Advisory Role: Roche and Merck Serono; Honoraria: Roche and Merck Serono; Research funding: Roche Fernando Rivera: Consultant or Advisory Role: Roche and Research Funding: Roche. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: EDR EA. Performed the experiments: EDR AGE BM JS MR JLM FR MJS CM EG MB EM AC PMP CFM AA IB EA. Analyzed the data: EDR EA. Contributed reagents/materials/analysis tools: EDR AGE BM JS MR JLM FR MJS CM EG MB EM AC PMP CFM AA IB EA. Wrote the paper: EDR EA.