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Research Article

Transcriptional Activation and Cell Cycle Block Are the Keys for 5-Fluorouracil Induced Up-Regulation of Human Thymidylate Synthase Expression

  • Alessio Ligabue,

    Affiliations: INSERM U696, Palaiseau, France, Laboratoire d'Optique et Biosciences, CNRS, Ecole Polytechnique, Palaiseau, France

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  • Gaetano Marverti,

    Affiliation: Dipartimento di Scienze Biomediche, Sezione di Chimica Biologica, University of Modena and Reggio Emilia, Modena, Italy

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  • Ursula Liebl,

    Affiliations: INSERM U696, Palaiseau, France, Laboratoire d'Optique et Biosciences, CNRS, Ecole Polytechnique, Palaiseau, France

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  • Hannu Myllykallio mail

    Hannu.myllykallio@polytechnique.edu

    Affiliations: INSERM U696, Palaiseau, France, Laboratoire d'Optique et Biosciences, CNRS, Ecole Polytechnique, Palaiseau, France

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  • Published: October 09, 2012
  • DOI: 10.1371/journal.pone.0047318

About the Authors

Alessio Ligabue, Ursula Liebl, Hannu Myllykallio
INSERM U696, Palaiseau, France
Alessio Ligabue, Ursula Liebl, Hannu Myllykallio
Laboratoire d'Optique et Biosciences, CNRS, Ecole Polytechnique, Palaiseau, France
Gaetano Marverti
Dipartimento di Scienze Biomediche, Sezione di Chimica Biologica, University of Modena and Reggio Emilia, Modena, Italy

Corresponding Author

Email: Hannu.myllykallio@polytechnique.edu

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: AL GM HM. Performed the experiments: AL GM. Analyzed the data: AL GM UL HM. Contributed reagents/materials/analysis tools: AL GM UL HM. Wrote the paper: AL UL HM.