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Research Article

Genome-Wide PhoB Binding and Gene Expression Profiles Reveal the Hierarchical Gene Regulatory Network of Phosphate Starvation in Escherichia coli

  • Chi Yang,

    Affiliation: Institute of Biomedical Informatics, Center for Systems and Synthetic Biology, National Yang Ming University, Taipei, Taiwan

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  • Tzu-Wen Huang,

    Affiliation: Division of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan

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  • Shiau-Yi Wen,

    Affiliation: Institute of Biomedical Informatics, Center for Systems and Synthetic Biology, National Yang Ming University, Taipei, Taiwan

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  • Chun-Yang Chang,

    Affiliation: Department of Agricultural Chemistry, National Taiwan University, Taipei, Taiwan

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  • Shih-Feng Tsai,

    Affiliation: Division of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan

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  • Whei-Fen Wu,

    Affiliation: Department of Agricultural Chemistry, National Taiwan University, Taipei, Taiwan

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  • Chuan-Hsiung Chang mail

    cchang@ym.edu.tw

    Affiliations: Institute of Biomedical Informatics, Center for Systems and Synthetic Biology, National Yang Ming University, Taipei, Taiwan, Center for Systems and Synthetic Biology, National Yang Ming University, Taipei, Taiwan

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  • Published: October 05, 2012
  • DOI: 10.1371/journal.pone.0047314

About the Authors

Chi Yang, Shiau-Yi Wen, Chuan-Hsiung Chang
Institute of Biomedical Informatics, Center for Systems and Synthetic Biology, National Yang Ming University, Taipei, Taiwan
Chuan-Hsiung Chang
Center for Systems and Synthetic Biology, National Yang Ming University, Taipei, Taiwan
Tzu-Wen Huang, Shih-Feng Tsai
Division of Molecular and Genomic Medicine, National Health Research Institutes, Miaoli, Taiwan
Chun-Yang Chang, Whei-Fen Wu
Department of Agricultural Chemistry, National Taiwan University, Taipei, Taiwan

Corresponding Author

Email: cchang@ym.edu.tw

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CY CHC SFT WFW. Performed the experiments: CY TWH SYW CYC. Analyzed the data: CY. Contributed reagents/materials/analysis tools: CHC WFW SFT. Wrote the paper: CY CHC WFW SFT.