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Research Article

Activating Nrf-2 Signaling Depresses Unilateral Ureteral Obstruction-Evoked Mitochondrial Stress-Related Autophagy, Apoptosis and Pyroptosis in Kidney

  • Shue Dong Chung,

    Affiliations: Department of Urology, Far East Memory Hospital, New Taipei City, Taiwan, Graduate Institution of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan, Department of Urology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan

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  • Ting Yu Lai,

    Affiliations: Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan, Department of Life Science, National Taiwan Normal University, Taipei, Taiwan

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  • Chiang Ting Chien mail,

    yhj5251@ntu.edu.tw (HJY); ctchien@ntnu.edu.tw (CTC)

    Affiliations: Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan, Department of Life Science, National Taiwan Normal University, Taipei, Taiwan

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  • Hong Jen Yu mail

    yhj5251@ntu.edu.tw (HJY); ctchien@ntnu.edu.tw (CTC)

    Affiliation: Department of Urology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan

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  • Published: October 10, 2012
  • DOI: 10.1371/journal.pone.0047299

About the Authors

Shue Dong Chung
Department of Urology, Far East Memory Hospital, New Taipei City, Taiwan
Shue Dong Chung
Graduate Institution of Clinical Medicine, National Taiwan University College of Medicine, Taipei, Taiwan
Shue Dong Chung, Hong Jen Yu
Department of Urology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan
Ting Yu Lai, Chiang Ting Chien
Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan
Ting Yu Lai, Chiang Ting Chien
Department of Life Science, National Taiwan Normal University, Taipei, Taiwan

Corresponding Authors

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: SDC CTC HJY. Performed the experiments: SDC TYL CTC. Analyzed the data: SDC TYL CTC HJY. Contributed reagents/materials/analysis tools: SDC TYL HJY. Wrote the paper: SDC TYL CTC HJY.